| Renal blood flow changes induced with endothelin-1 and fenoldopam mesylate at quantitative Doppler US: initial results in a canine study. | |
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MedLine Citation:
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PMID: 11323466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate quantitative Doppler ultrasonography (US) for assessing renal blood flow changes induced with endothelin-1 (ET-1) and fenoldopam mesylate in conscious dogs. MATERIALS AND METHODS: A blood flow probe was surgically implanted around the renal artery in eight adult dogs. Color and power Doppler US images were acquired in conscious restrained dogs during intravenous infusion of ET-1 and fenoldopam mesylate. Simultaneous with imaging, blood flow through the renal artery was measured with the implanted probe. The color level of the images within the region representing the kidney was analyzed to derive flow indices. These indices were compared with direct-flow measurements. RESULTS: The flow indices, color-weighted flow area (CWFA), and percentage of area of color, derived from color and power Doppler US images, correlated linearly with direct flow. The mean color level of color and power Doppler US images correlated weakly with direct flow. Pre- versus postinfusion CWFA decreased with all ET-1 infusions (P < or =.032). Infusion of fenoldopam mesylate increased CWFA in all cases (P < or =.032). CONCLUSION: Quantitative Doppler US enabled successful measurement of the flow changes induced with ET-1 and fenoldopam mesylate. Quantitative Doppler US is potentially useful as a noninvasive surrogate endpoint in evaluating the action of various therapeutic agents. |
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Authors:
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C M Sehgal; P H Arger; A C Silver; J A Patton; H M Saunders; A Bhattacharyya; C P Bell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiology Volume: 219 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-04-27 Completed Date: 2001-05-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 419-26 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104-6086, USA. sehgal@oasis.rad.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology* Blood Flow Velocity / drug effects Dogs Endothelin-1 / pharmacology* Fenoldopam / pharmacology* Male Renal Circulation / drug effects* Ultrasonography, Doppler* Ultrasonography, Doppler, Color Vasoconstrictor Agents / pharmacology* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Endothelin-1; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 67227-56-9/Fenoldopam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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