Document Detail

Renal blood flow autoregulation in blood pressure control.
MedLine Citation:
PMID:  11753089     Owner:  NLM     Status:  MEDLINE    
Although the kidney strives to maintain its perfusion within tight boundaries, considerable blood flow fluctuations do occur. The reasons for this are the rather slow acting compensatory mechanisms of renal blood flow autoregulation, the effects of renal nerves, hormonal influences, etc. It seems that variations in renal perfusion can exert a major influence on renal excretory functions, on renin release and on blood pressure. The clinical importance of renal blood flow variability is not fully understood. In many situations, the absence of normal cardiovascular oscillations seems to be a risk factor. Large fluctuations in perfusion pressure to the kidney, however, in the long run, may induce target organ damage.
Pontus B Persson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  11     ISSN:  1062-4821     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Johannes Müller Institute of Physiology, Humboldt University (Charité), Berlin, Germany.
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MeSH Terms
Blood Pressure / physiology*
Diuresis / physiology
Homeostasis* / physiology*
Hypertension / etiology
Natriuresis / physiology
Renal Circulation / physiology*
Renin / metabolism
Reg. No./Substance:

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