Document Detail


Renal biopsy in patients with unexplained renal impairment and normal kidney size.
MedLine Citation:
PMID:  2602535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report renal biopsy findings in 109 patients with unexplained renal impairment (serum creatinine greater than 0.15 mmol/l) and normal-sized non-obstructed kidneys. The most common histological lesions were interstitial nephritis, rapidly progressive glomerulonephritis and a variety of other types of glomerulonephritis. The groups could not be distinguished by the presence or absence of hypertension, haematuria, proteinuria, or features of systemic disease. However interstitial nephritis was found more frequently in patients presenting with one or none of these features and rapidly progressive glomerulonephritis in patients presenting with three or more. All four patients with none of these features had interstitial lesions. Fifty-two per cent of patients with interstitial nephritis improved and 60 per cent of the patients with rapidly progressive glomerulonephritis who received immunosuppressive treatment improved or remained stable with treatment. The benefits of a biopsy diagnosis were almost wholly confined to these two groups. Complications were recorded in nine patients - prolonged macroscopic haematuria in six and symptomatic perirenal haematomata in three. Six required blood transfusion. One required nephrectomy to control haemorrhage and subsequently died. Percutaneous renal biopsy is not without risk in patients with renal impairment but the benefits of diagnosing interstitial nephritis and rapidly progressive glomerulonephritis outweigh the disadvantages.
Authors:
K Farrington; D A Levison; R N Greenwood; W R Cattell; L R Baker
Related Documents :
6218335 - Iga nephropathy. correlation of clinical and histologic features.
1330195 - Clinicopathological study of nephroblastomas in ibadan.
8154495 - Plasmapheresis reduces proteinuria and serum capacity to injure glomeruli in patients w...
19203545 - Clinicopathological features and prognosis in immunoglobulin light and heavy chain depo...
18019935 - Transfusion triggers.
6858875 - Cardiac disease after radiation therapy for hodgkin's disease: analysis of 48 patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  70     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1990-02-06     Completed Date:  1990-02-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-33     Citation Subset:  IM    
Affiliation:
Department of Nephrology, St. Bartholomew's Hospital, London.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Female
Glomerulonephritis / pathology*
Humans
Kidney / pathology*
Kidney Function Tests
Male
Middle Aged
Nephritis, Interstitial / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An audit of doctor's management of patients with chest pain in the accident and emergency department...
Next Document:  Possible evidence for a variant of myasthenia gravis based on HLA and acetylcholine receptor antibod...