Document Detail

Renal artery stenosis and nephrotic syndrome: a rare combination in an infant.
MedLine Citation:
PMID:  12644923     Owner:  NLM     Status:  MEDLINE    
We describe an uncommon pediatric finding of unilateral renal artery stenosis, which presented as nephrotic syndrome, hypertension, failure to thrive, and hyponatremia. The child was a previously well 8-month-old male who looked well but had mild periorbital edema with severe hypertension. After 3 days of captopril therapy, the nephrotic-range proteinuria significantly improved. However, the hypertension persisted. Renal imaging revealed a small left kidney with reduced parenchymal uptake and no significant excretion. A renal angiogram demonstrated left renal artery stenosis with increased left renal vein renin activity. The hypertension resolved within 24 h of a left nephrectomy, but non-nephrotic-range proteinuria persisted for 8 months post operatively. Pathology of the left kidney was consistent with fibromuscular dysplasia. Although a few glomeruli (1%) had changes consistent with focal segmental glomerulosclerosis, such a few abnormal glomeruli were unlikely to account for the nephrotic syndrome. Hypertension-induced changes in the unaffected right kidney probably caused the nephrotic-range proteinuria.
Mia E Lang; Manjula Gowrishankar
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2003-02-26
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  18     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-19     Completed Date:  2003-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  276-9     Citation Subset:  IM    
Division of Pediatric Nephrology, Department of Pediatrics, University of Alberta Hospitals, 2C3 WMHSC, Edmonton, AB T6G 2R7, Canada.
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MeSH Terms
Hypertension, Renal / etiology
Nephrotic Syndrome / etiology*
Proteinuria / etiology
Renal Artery Obstruction / complications*,  diagnosis

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