Document Detail

Renal artery calcium: relationship to systemic calcified atherosclerosis.
MedLine Citation:
PMID:  17390546     Owner:  NLM     Status:  MEDLINE    
In this study we tested the hypothesis that calcium due to atherosclerosis in the renal arteries would be significantly associated with calcium in multiple other vascular beds, independent of traditional risk factors for cardiovascular disease (CVD). Electron beam computed tomography was conducted in 1461 consecutive asymptomatic patients free of clinical CVD to determine the presence and extent of calcium in the renal arteries, coronary and non-coronary vasculature and the aortic and mitral annuli. The overall prevalence for calcium in either renal artery was 18.0%, with men having a significantly higher prevalence (20.2%) than women (15.0%) [p = 0.01]. Renal artery calcium (RAC) was significantly correlated with calcium located in the carotids, coronaries, thoracic aorta, abdominal aorta and iliac arteries and calcium in the mitral and aortic annuli (r range = 0.22-0.37). In a multi-variable model containing the traditional CVD risk factors, the presence of calcium in the renal arteries was significantly associated with age, male sex and a diagnosis of hypertension. After adjustment for these variables, the presence of calcium in the thoracic or abdominal aorta was significantly associated with RAC (OR = 2.1 and 2.0, respectively; p < 0.01 for both). The sensitivity for prevalent RAC was highest in those individuals with any calcium in the abdominal aorta (94.5%). In conclusion, calcium related to atherosclerosis in the renal arteries is highly associated with atherosclerotic calcification in other vascular beds, especially the aorta, and the valvular annuli. These relationships are independent of traditional CVD risk factors.
Matthew A Allison; Dominic DiTomasso; Michael H Criqui; Robert D Langer; C Michael Wright
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  11     ISSN:  1358-863X     ISO Abbreviation:  Vasc Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-04-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  232-8     Citation Subset:  IM    
Departments of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA.
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MeSH Terms
Aorta, Abdominal
Aorta, Thoracic
Aortic Diseases / epidemiology
Atherosclerosis / epidemiology*,  radiography
Calcinosis / epidemiology*,  radiography
California / epidemiology
Carotid Artery Diseases / epidemiology
Cohort Studies
Coronary Artery Disease / epidemiology
Heart Valve Diseases / epidemiology*,  radiography
Iliac Artery
Logistic Models
Middle Aged
Odds Ratio
Predictive Value of Tests
Renal Artery Obstruction / epidemiology*,  radiography
Risk Assessment
Risk Factors
Sensitivity and Specificity
Tomography, X-Ray Computed

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