| Renal arterial blood flow measurement by breath-held MRI: Accuracy in phantom scans and reproducibility in healthy subjects. | |
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MedLine Citation:
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PMID: 20373395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates reliability of current technology for measurement of renal arterial blood flow by breath-held velocity-encoded MRI. Overall accuracy was determined by comparing MRI measurements with known flow in controlled-flow-loop phantom studies. Measurements using prospective and retrospective gating methods were compared in phantom studies with pulsatile flow, not revealing significant differences. Phantom study results showed good accuracy, with deviations from true flow consistently below 13% for vessel diameters 3mm and above. Reproducibility in human subjects was evaluated by repeated studies in six healthy control subjects, comparing immediate repetition of the scan, repetition of the scan plane scouting, and week-to-week variation in repeated studies. The standard deviation in the 4-week protocol of repeated in vivo measurements of single-kidney renal flow in normal subjects was 59.7 mL/min, corresponding with an average coefficient of variation of 10.55%. Comparison of renal arterial blood flow reproducibility with and without gadolinium contrast showed no significant differences in mean or standard deviation. A breakdown among error components showed corresponding marginal standard deviations (coefficients of variation) 23.8 mL/min (4.21%) for immediate repetition of the breath-held flow scan, 39.13 mL/min (6.90%) for repeated plane scouting, and 40.76 mL/min (7.20%) for weekly fluctuations in renal blood flow. |
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Authors:
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Samuel Dambreville; Arlene B Chapman; Vicente E Torres; Bernard F King; Ashley K Wallin; David H Frakes; Ajit P Yoganathan; Sameera R Wijayawardana; Kirk Easley; Kyongtae T Bae; Marijn E Brummer; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-07 Completed Date: 2010-07-15 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 940-50 Citation Subset: IM |
Affiliation:
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Georgia Institute of Technology, Atlanta, Georgia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / physiology Cardiac-Gated Imaging Techniques / methods Contrast Media Female Gadolinium DTPA Humans Image Processing, Computer-Assisted Kidney / blood supply* Magnetic Resonance Imaging / methods* Male Phantoms, Imaging Pulsatile Flow / physiology Renal Artery / physiology* Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00039/RR/NCRR NIH HHS; R01 DK044863-17/DK/NIDDK NIH HHS; U01-DK-56956/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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