Document Detail

Renal adaptation to the failing heart. Understanding the cascade of responses.
MedLine Citation:
PMID:  8202419     Owner:  NLM     Status:  MEDLINE    
Progressive systolic dysfunction of the heart results in a broad array of physiologic compensatory mechanisms within the kidney. These mechanisms are primarily stimulated by diminution of the effective arterial blood volume and resultant activation of a biochemical cascade of neurohormonal responses, including activation of the renin-angiotensin-aldosterone system and enhanced release of norepinephrine, arginine vasopressin, prostaglandins, endothelin, and atrial natriuretic peptide. The interaction of these neurohormonal systems within the kidney is complex. Vasoconstriction induced by angiotensin II, arginine vasopressin, and catecholamines may decrease renal perfusion by both endocrine and neural actions. In contrast, systemic pressures may rise, which may facilitate perfusion.
D J Riley; M Weir; G L Bakris
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Postgraduate medicine     Volume:  95     ISSN:  0032-5481     ISO Abbreviation:  Postgrad Med     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-06     Completed Date:  1994-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-6, 149-50     Citation Subset:  AIM; IM    
Department of Medicine, University of Texas Health Science Center at San Antonio.
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MeSH Terms
Adaptation, Physiological*
Aldosterone / physiology
Angiotensin II / physiology
Arginine Vasopressin / physiology
Atrial Natriuretic Factor / physiology
Blood Volume
Endothelins / physiology
Heart Failure / complications*,  physiopathology*
Kidney Diseases / etiology*,  physiopathology*
Norepinephrine / physiology
Prostaglandins / physiology
Renal Circulation*
Renin-Angiotensin System / physiology
Reg. No./Substance:
0/Endothelins; 0/Prostaglandins; 11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 51-41-2/Norepinephrine; 52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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