| Renal acid excretion in early infancy. | |
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MedLine Citation:
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PMID: 9090674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In early infancy, complex disorders of acid base metabolism are more frequent than in any other age group, with a predisposition to metabolic acidosis due to an age-related low renal capacity for acid excretion and an unphysiologically high actual renal acid load in nutrition with common formulas. Recently in preterm and small-for-gestational-age infants, persistent maximum renal net acid excretion (NAE) with subnormal or normal blood acid base status, impaired weight gain, and adaptive hormonal reactions have been observed. Incipient late metabolic acidosis is one example of a mixed disorder of acid base metabolism with maximum renal NAE in early infancy. Alkali therapy is highly effective and can be realized both on an individual basis, using urine pH screening as a diagnostic criterium for maximum renal acid stimulation, or on a general preventive level using modified standard formula with a reduced actual renal NAE similar to that seen on alimentation with human milk. From an integrated point of view, the low glomerular filtration rate and renal capacity for acid excretion beyond the developmental age of more than 44 weeks, may well be interpreted as the result of a specific adaptation to breast feeding sparing energy, and thus an evolutionary advantage for the survival of mother and child. |
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Authors:
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F Manz; H Kalhoff; T Remer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 11 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-20 Completed Date: 1997-06-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 231-43 Citation Subset: IM |
Affiliation:
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Research Institute of Child Nutrition, Dortmund, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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physiology Acids / urine* Humans Infant Infant, Newborn Kidney / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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