| Renal Sympathetic Denervation for the Treatment of Systemic Hypertension. | |
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MedLine Citation:
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PMID: 22717655 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Systemic hypertension is a common cardiovascular problem that often cannot be fully treated with existing non-pharmacologic and pharmacologic measures. A catheter-based strategy which denervates the renal afferent and efferent autonomic nervous system has been developed for the treatment of drug-resistant hypertension. In early clinical trials this procedure was shown to be both feasible and safe in reducing blood pressure in patients with uncontrolled hypertension receiving treatment with a minimum of 3 antihypertensive drugs. In addition, this procedure has been associated with decreased renin secretion, preservation of renal function, improved glucose tolerance, and a reduction in left ventricular hypertrophy. The long-term effects of this procedure (beyond 3 years) still need to be determined. A large 530 patient sham-controlled trial is now in progress. |
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Authors:
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Gordon M Burke; Domenic A Sica; William H Frishman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-20 |
Journal Detail:
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Title: Cardiology in review Volume: - ISSN: 1538-4683 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304686 Medline TA: Cardiol Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Dept. of Internal Medicine, Boston University Medical Center, Boston Ma., †Dept. of Medicine & Pharmacology, Div. of Nephrology, Virginia Commonwealth University Health System, Richmond, Va., and *Dept. of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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