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Renal Sympathetic Denervation for the Treatment of Systemic Hypertension.
MedLine Citation:
PMID:  22717655     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Systemic hypertension is a common cardiovascular problem that often cannot be fully treated with existing non-pharmacologic and pharmacologic measures. A catheter-based strategy which denervates the renal afferent and efferent autonomic nervous system has been developed for the treatment of drug-resistant hypertension. In early clinical trials this procedure was shown to be both feasible and safe in reducing blood pressure in patients with uncontrolled hypertension receiving treatment with a minimum of 3 antihypertensive drugs. In addition, this procedure has been associated with decreased renin secretion, preservation of renal function, improved glucose tolerance, and a reduction in left ventricular hypertrophy. The long-term effects of this procedure (beyond 3 years) still need to be determined. A large 530 patient sham-controlled trial is now in progress.
Authors:
Gordon M Burke; Domenic A Sica; William H Frishman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-20
Journal Detail:
Title:  Cardiology in review     Volume:  -     ISSN:  1538-4683     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Dept. of Internal Medicine, Boston University Medical Center, Boston Ma., †Dept. of Medicine & Pharmacology, Div. of Nephrology, Virginia Commonwealth University Health System, Richmond, Va., and *Dept. of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY.
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