Document Detail


Renal Sympathetic Denervation Modulates Ventricular Electrophysiology and Has a Protective Effect on Ischemia-induced Ventricular Arrhythmia.
MedLine Citation:
PMID:  25172887     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recently, a beneficial effect of renal sympathetic denervation (RSD) has been seen in patients with ventricular electrical storm. However, the effect of RSD on ventricular electrophysiology remains unclear. Thirty-three mongrel dogs were included in the present study. RSD was performed by radiofrequency ablation of the adventitial surface of the renal artery. In Group 1 (n = 8), programmed stimulation was performed before and after RSD to determinate ventricular effective refractory period (ERP) and action potential duration (APD) restitution properties. The same parameters were measured in 5 other animals that underwent sham RSD to serves as controls. In Group 2 (n = 10), acute myocardial ischemia (AMI) was induced by ligating the proximal left anterior descending coronary artery after the performance of RSD and the ventricular arrhythmia (VA) incidence was calculated during 1-h recording. In another 10 dogs (Group 3), AMI was induced and VA was measured with sham RSD. In Group 1, RSD significantly prolonged ventricular ERP and APD, reduced the maximum slope (Smax) of the restitution curve and suppressed APD alternans at each site. RSD also significantly decreased the spatial dispersions of ERP, APD and Smax. In the 5 control animals, no significant electrophysiological change was detected after sham RSD. The occurrence of spontaneous VA during 1-h of AMI in Group 2 was significantly lower than that in Group 3. These data suggest that RSD stabilizes ventricular electrophysiological properties in normal hearts and reduces the occurrence of VA in AMI hearts. This article is protected by copyright. All rights reserved.
Authors:
Bing Huang; Lilei Yu; Bo He; Zhibing Lu; Songyun Wang; Wenbo He; Kang Yang; Kai Liao; Ling Zhang; Hong Jiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-28
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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