| Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular events. | |
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MedLine Citation:
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PMID: 20837881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fat in the renal sinus (RS), a region of the kidney in which low pressure venous and lymphatic vessels are present, may indirectly influence blood pressure. The purpose of this study was to assess the association between RS fat and control of blood pressure on receipt of antihypertensive medications. A total of 205 participants aged 55 to 85 years at risk for cardiovascular events underwent MRI assessments of abdominal and RS fat, measurement of blood pressure, and determination of the number of prescribed antihypertensive medications. Multivariable linear regression was used to determine associations among RS fat, blood pressure, and the number of prescribed antihypertensive medications. Abdominal fat averaged 416±160 cm(3) (median and interquartile range of 396 cm(3) and 308 to 518 cm(3)); intraperitoneal fat averaged 141±73 cm(3) (median and interquartile range of 129 cm(3) and 86 to 194 cm(3)); and RS fat averaged 4.6±3.2 cm(3) (median and interquartile range of 4.2 cm(3) and 2.2 to 6.6 cm(3)). After accounting for age, sex, height, body mass index, and intraperitoneal fat, RS fat correlated with the number of prescribed antihypertensive medications (P=0.010), stage II hypertension (P=0.02), and renal size (P≤0.001). In conclusion, after accounting for other body fat depots and risk factors for hypertension, RS fat volume is associated with the number of prescribed antihypertensive medications and stage II hypertension. These results indicate that further studies are warranted to determine whether fat accumulation in the RS promotes hypertension. |
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Authors:
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Haroon L Chughtai; Timothy M Morgan; Michael Rocco; Brandon Stacey; Tina E Brinkley; Jingzhong Ding; Barbara Nicklas; Craig Hamilton; W Gregory Hundley |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-13 |
Journal Detail:
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Title: Hypertension Volume: 56 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-10 Revised Date: 2011-05-04 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 901-6 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00542503 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Fat
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pathology* Adipose Tissue / pathology* Antihypertensive Agents / therapeutic use Body Composition Humans Hypertension / drug therapy, pathology*, prevention & control Kidney / blood supply, pathology* Linear Models Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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MO1-RR07122/RR/NCRR NIH HHS; P30 AG021332-09/AG/NIA NIH HHS; P30AG21332/AG/NIA NIH HHS; R01 HL076438-03/HL/NHLBI NIH HHS; R01 HL076438-05/HL/NHLBI NIH HHS; R01HL076438/HL/NHLBI NIH HHS; R33 CA121296-04/CA/NCI NIH HHS; R33CA1219601/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
| Comments/Corrections | |
Comment In:
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Hypertension. 2010 Nov;56(5):814-5
[PMID:
20837879
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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