Document Detail


Renal Resistive Index Better Predicts the Occurrence of Acute Kidney Injury Than Cystatin C.
MedLine Citation:
PMID:  23042202     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: To determine the predictive value of the renal resistive index (RI) and cystatin C values in serum (SCys) and urine (UCys) in the development of acute kidney injury (AKI) in critically ill patients with severe sepsis or polytrauma. DESIGN AND SETTING:: prospective, double-centre, descriptive study. PATIENTS AND PARTICIPANTS:: 58 patients with severe sepsis (n = 28) or polytrauma (n = 30). MEASUREMENTS AND RESULTS:: RI, SCys and UCys were measured within the 12 hours following admission (Day 1, D1) to the intensive care unit (ICU). Renal function was assessed using the AKI network classification: On day 3 (D3), 40 patients were stage 0 or 1, and 18 were stage 2 or 3. Patients with AKI stage 2 or 3 had significantly higher RI (0.80 vs. 0.66, p < 0.0001), SCys (1.23 vs. 0.68 mg/L, p = 0.0002) and UCys (3.32 vs. 0.09 mg/L, p = 0.0008). They also had higher SAPS II, arterial lactate and ICU mortality. In multivariate analysis, a RI > 0.707 on D1 was the only parameter predictive of the development of AKI stage 2 or 3 on D3 (p=0.0004). In the subgroup of patients with AKI stage 2 or 3 on D1, RI remained the only parameter associated with persistent AKI on D3 (p=0.016). CONCLUSION:: In multivariate analysis comparing the predictive value of RI, SCys and UCys, RI was the only parameter predictive of AKI stage 2 or 3 on D3. RI seems to be a promising tool to assess the risk of AKI.
Authors:
D Schnell; S Deruddre; A Harrois; J Pottecher; C Cosson; N Adoui; D Benhamou; E Vicaut; E Azoulay; J Duranteau
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  -     ISSN:  1540-0514     ISO Abbreviation:  Shock     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a: Université Paris Sud-11, Assistance Publique Hôpitaux de Paris, Hôpital de Bicêtre, Département d'Anesthésie Réanimation, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. b: Université Paris Diderot-Paris 7, Assistance Publique Hôpitaux de Paris, Hôpital Saint Louis, Service de Réanimation Médicale, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France. c: Université Paris Sud-11, Assistance Publique Hôpitaux de Paris, Hôpital de Bicêtre, Laboratoire de Biochimie, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. d: Université Paris Diderot-Paris 7, Assistance Publique Hôpitaux de Paris, Hôpital Saint Louis, Laboratoire de Biochimie, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France. e: AP-HP, Centre Hospitalier Universitaire Lariboisière - Fernand Widal, Unité de Recherche Clinique; ; Laboratoire d'Etude de la Microcirculation, EA 3509, Université Paris 7, Paris, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A Combined Trauma Model of Chest and Abdominal Trauma With Hemorrhagic Shock - Description of a new ...
Next Document:  Gene Polymorphisms in the Heme Degradation Pathway and Outcome of Severe Human Sepsis.