| Renal Monoclonal Immunoglobulin Deposition Disease: A Report of 64 Patients from a Single Institution. | |
| | |
MedLine Citation:
|
PMID: 22156754 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background and objectivesTo better define the clinical-pathologic spectrum and prognosis of monoclonal immunoglobulin deposition disease (MIDD), this study reports the largest series.Design, setting, participants, & measurementsCharacteristics of 64 MIDD patients who were seen at Mayo Clinic are provided.ResultsOf 64 patients with MIDD, 51 had light chain deposition disease, 7 had heavy chain deposition disease, and 6 had light and heavy chain deposition disease. The mean age at diagnosis was 56 years, and 23 patients (36%) were ≤50 years of age. Clinical evidence of dysproteinemia was present in 62 patients (97%), including multiple myeloma in 38 (59%). M-spike was detected on serum protein electrophoresis in 47 (73%). Serum free light chain ratio was abnormal in all 51 patients tested. Presentation included renal insufficiency, proteinuria, hematuria, and hypertension. Nodular mesangial sclerosis was seen in 39 patients (61%). During a median of 25 months of follow-up (range, 1-140) in 56 patients, 32 (57%) had stable/improved renal function, 2 (4%) had worsening renal function, and 22 (39%) progressed to ESRD. The mean renal and patient survivals were 64 and 90 months, respectively. The disease recurred in three of four patients who received a kidney transplant.ConclusionsPatients with MIDD generally present at a younger age than those with light chain amyloidosis or light chain cast nephropathy. Serum free light chain ratio is abnormal in all MIDD patients, whereas only three-quarters have abnormal serum protein electrophoresis. The prognosis for MIDD is improving compared with historical controls, likely reflecting earlier detection and improved therapies. |
| | |
Authors:
|
Samih H Nasr; Anthony M Valeri; Lynn D Cornell; Mary E Fidler; Sanjeev Sethi; Vivette D D'Agati; Nelson Leung |
Related Documents
:
|
21286344 - Comparison of adverse effects related to pegylated interferon-based therapy for patient... 10402334 - Somatosensory evoked potentials by paraspinal stimulation in acute transverse myelitis. 2720014 - Visual evoked potentials in dementia: a meta-analysis and empirical study of alzheimer'... 7969244 - Brainstem reflexes in patients with olivopontocerebellar atrophy. 86264 - Renal handling of beta-2-microglobulin, amylase and albumin in acute pancreatitis. 20051694 - Predictors of vascular events after ischemic stroke: the china ischemic stroke registry... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-8 |
Journal Detail:
|
Title: Clinical journal of the American Society of Nephrology : CJASN Volume: - ISSN: 1555-905X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Laboratory Medicine and Pathology and. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dialysis Modality and Outcomes in Kidney Transplant Recipients.
Next Document: Cerebrospinal Fluid Proteins Predict Longitudinal Hippocampal Degeneration in Early-stage Dementia o...