| Renal insufficiency is independently associated with a distal distribution pattern of symptomatic lower-limb atherosclerosis. | |
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MedLine Citation:
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PMID: 20060759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The purpose of this study was to assess the impact of renal insufficiency (RI) on the distribution pattern of peripheral arterial disease (PAD). We hypothesised that RI is associated with a distally accentuated involvement of the peripheral arterial tree. DESIGN: This is a retrospective analysis. MATERIALS AND METHODS: Analysis was based on a consecutive series of 2709 patients with chronic PAD of atherosclerotic origin undergoing primary endovascular treatment of lower-extremity arteries. Atherosclerotic pattern was grouped into femoropopliteal (n=2085) and infragenicular (n=892) disease according to target lesions treated while using iliac disease (n=1133) as reference. Univariable and multivariable multinomial regression analyses were performed to assess relation with RI. Results are shown as relative risk ratio (RRRs) with 95% confidence intervals (95% CIs). A p<0.05 was considered statistically significant. RI was defined as glomerular filtration rate (GFR)<60 ml min(-1) 1.73 m(-2). RESULTS: Presence of RI was an independent risk factor for a centrifugal lesion pattern (RRR 1.48, 95% CI: 1.17-1.86, p=0.001). Moreover, a decrease in GFR by 10 ml min(-1) 1.73 m(-2) was associated with an RRR of 1.08 for below-the-knee arterial disease (95% CI: 1.03-1.13, p=0.003). CONCLUSION: Presence and severity of RI are independent predictors of a distal obstructive pattern in patients with symptomatic PAD. |
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Authors:
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S Wasmuth; I Baumgartner; D-D Do; T Willenberg; A Saguner; M Zwahlen; N Diehm |
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Publication Detail:
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Type: Journal Article Date: 2010-01-08 |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 39 ISSN: 1532-2165 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: England |
Other Details:
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Languages: eng Pagination: 591-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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University Clinic of Angiology, Swiss Cardiovascular Center, Inselspital, University Hospital of Bern, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiography, Digital Subtraction Atherosclerosis / epidemiology, etiology*, radiography Cardiovascular Diseases / epidemiology, etiology Female Glomerular Filtration Rate Humans Logistic Models Lower Extremity / blood supply* Male Middle Aged Prevalence Renal Insufficiency / complications*, epidemiology, physiopathology Retrospective Studies Risk Assessment Risk Factors Severity of Illness Index Switzerland / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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