Document Detail


Renal function in infants with sickle cell anemia: baseline data from the BABY HUG trial.
MedLine Citation:
PMID:  19880138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To examine the feasibility and accuracy of glomerular filtration rate (GFR) measurements in infants with sickle cell anemia (SCA). STUDY DESIGN: The NHLBI/NICHD-sponsored Phase III randomized double-blinded placebo-controlled trial (BABY HUG) tests the hypothesis that hydroxyurea can prevent chronic organ damage in SCA. GFR elevation is a coprimary endpoint, measured quantitatively by technetium 99m-labeled diethylenetriaminepentaacetic acid (DTPA) plasma clearance and estimated by the Schwartz equation with height and creatinine. RESULTS: Baseline DTPA GFR measurement was attempted in 191 infants; 176 of 184 completed studies (96%) were interpretable. Average age (mean +/- 1SD) was 13.7 +/- 2.6 months. Average DTPA GFR was 125.2 +/- 34.4 (range 40.2-300.9, normal 91.5 +/- 17.8 mL/min/1.73m(2)), while Schwartz estimates were higher at 184.4 +/- 55.5 mL/min/1.73m(2). DTPA GFR was correlated with Schwartz GFR (r(2) = 0.0658, P = .0012); also with age, weight, height, and kidney volume (all P < .002); but not with hemoglobin, HbF, white blood cell count, reticulocytes, medical events, or splenic function. CONCLUSIONS: Quantitative GFR measurement is feasible but variable among infants with SCA. Schwartz GFR estimates are not highly correlated with quantitative DTPA GFR values. Baseline GFR measurements suggest that renal dysfunction in SCA, evidenced by glomerular hyperfiltration, begins during infancy.
Authors:
Russell E Ware; Renee C Rees; Sharada A Sarnaik; Rathi V Iyer; Ofelia A Alvarez; James F Casella; Barry L Shulkin; Eglal Shalaby-Rana; C Frederic Strife; John H Miller; Peter A Lane; Winfred C Wang; Scott T Miller;
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Publication Detail:
Type:  Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  156     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  66-70.e1     Citation Subset:  AIM; IM    
Affiliation:
St. Jude Children's Research Hospital, Memphis, TN 38105, USA. russell.ware@stjude.org
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MeSH Terms
Descriptor/Qualifier:
Anemia, Sickle Cell / physiopathology*
Creatinine / blood
Glomerular Filtration Rate
Humans
Infant
Kidney / physiopathology*
Pentetic Acid / blood
Spleen / physiopathology*
Grant Support
ID/Acronym/Agency:
N01-HB-07150/HB/NHLBI NIH HHS; N01-HB-07151/HB/NHLBI NIH HHS; N01-HB-07152/HB/NHLBI NIH HHS; N01-HB-07153/HB/NHLBI NIH HHS; N01-HB-07154/HB/NHLBI NIH HHS; N01-HB-07155/HB/NHLBI NIH HHS; N01-HB-07156/HB/NHLBI NIH HHS; N01-HB-07157/HB/NHLBI NIH HHS; N01-HB-07158/HB/NHLBI NIH HHS; N01-HB-07159/HB/NHLBI NIH HHS; N01-HB-07160/HB/NHLBI NIH HHS
Chemical
Reg. No./Substance:
60-27-5/Creatinine; 67-43-6/Pentetic Acid
Investigator
Investigator/Affiliation:
Catherine Driscoll / ; Caterina Minniti / ; Lori Luchtman-Jones / ; Brenda Martin / ; Barbara Speller-Brown / ; Courtney Thornburg / ; Sherri Zimmerman / ; William Schultz / ; Tracy Kelly / ; Jacqueline Davis / ; Sohail Rana / ; Caroline K Reed / ; Jhoanna Jhoanna Roa / ; Patricia Houston / ; Erin Yeagley / ; Phillip Seaman / ; Jeffrey Keefer / ; Sue Dixon / ; Melvin J Reinhardt / ; M Robert De Jong / ; Ram Kalpatthi / ; Sherron Jackson / ; Betsy Rackoff / ; Lisa Kuisel / ; Deborah Disco / ; Lane Faughnan / ; Lynn Wynn / ; Kathy Rey / ; Rebecca S Gonzalez / ; Arnold M Strashun / ; Julio Barredo / ; Stuart Toledano / ; Tally Hustace / ; Glenda Thomas / ; Deborah Estess / ; Freida McKenzie / ; Mary Gail Smith / ; Tom Hogan / ; Zora R Rogers / ; Cindy Cochran / ; Jennifer Marshall / ; Leah Adix / ; Thomas Howard / ; Jennifer McDuffie / ; Roy McDonald / ; Kim Whelan / ; Lori Luck / ; Mary Lou MacDermott / ; R Clark Brown / ; Ifeyinwa Osunkwo / ; Anne Herry / ; Eldrida Randall / ; Korin Cherry / ; Sharada Sarniak / ; Wanda Whitten-Shurney / ; Mary Murphy / ; Rana Khatib / ; Bruce Thompson / ; Daner Li / ; Xiangke Huang /

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