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Renal Function Is Impaired in Small for Gestational Age Premature Infants.
MedLine Citation:
PMID:  23035924     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objectives: Small for gestational age (SGA) premature infants are at increased risk for complications. We aimed to evaluate if SGA infants are at higher risk for presenting renal insufficiency in the newborn period compared to appropriate for gestational age (AGA) premature infants. Methods: We conducted a retrospective case-control study of infants ≤ 34 weeks gestation. Markers of renal function based upon the Acute Kidney Injury Network were compared between both groups. Results: Twenty SGA infants were compared to twenty AGA infants matching in sex and gestational age. SGA infants had higher serum creatinine on day of life (DOL) 1 (p= 0.014) and DOL 3 (p=0.05) and a higher overall maximum creatinine concentration (p=0.013). They were also more likely to have an increase in serum creatinine more than 0.3 mg/dl in a 48-hour period (OR: 7.8, p= 0.008) and increase in serum creatinine more than 50% in a 48-hour period (OR: 12.4, p=0.002). Urine output (ml/kg/hr) was significantly less in the SGA group on DOL 3 (p= 0.002) and DOL 7 (p= 0.017). Conclusions: SGA infants are at increased risk for renal insufficiency during the neonatal period, thereby implying the need for special considerations in their fluid and medication management.
Authors:
Jonathan Davies; Mohamed El-Dib; An Massaro; Hany Aly
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Pediatrics, Washington, DC, USA.
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