| Renal function following long-term weight loss in individuals with abdominal obesity on a very-low-carbohydrate diet vs high-carbohydrate diet. | |
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MedLine Citation:
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PMID: 20338292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A frequently cited concern of very-low-carbohydrate diets is the potential for increased risk of renal disease associated with a higher protein intake. However, to date, no well-controlled randomized studies have evaluated the long-term effects of very-low-carbohydrate diets on renal function. To study this issue, renal function was assessed in 68 men and women with abdominal obesity (age 51.5+/-7.7 years, body mass index [calculated as kg/m(2)] 33.6+/-4.0) without preexisting renal dysfunction who were randomized to consume either an energy-restricted ( approximately 1,433 to 1,672 kcal/day), planned isocaloric very-low-carbohydrate (4% total energy as carbohydrate [14 g], 35% protein [124 g], 61% fat [99 g]), or high-carbohydrate diet (46% total energy as carbohydrate [162 g], 24% protein [85 g], 30% fat [49 g]) for 1 year. Body weight, serum creatinine, estimated glomerular filtration rate and urinary albumin excretion were assessed before and after 1 year (April 2006-July 2007). Repeated measures analysis of variance was conducted. Weight loss was similar in both groups (very-low-carbohydrate: -14.5+/-9.7 kg, high-carbohydrate: -11.6+/-7.3 kg; P=0.16). By 1 year, there were no changes in either group in serum creatinine levels (very-low-carbohydrate: 72.4+/-15.1 to 71.3+/-13.8 mumol/L, high-carbohydrate: 78.0+/-16.0 to 77.2+/-13.2 mumol/L; P=0.93 time x diet effect) or estimated glomerular filtration rate (very-low-carbohydrate: 90.0+/-17.0 to 91.2+/-17.8 mL/min/1.73 m(2), high-carbohydrate: 83.8+/-13.8 to 83.6+/-11.8 mL/min/1.73 m(2); P=0.53 time x diet effect). All but one participant was classified as having normoalbuminuria at baseline, and for these participants, urinary albumin excretion values remained in the normoalbuminuria range at 1 year. One participant in high-carbohydrate had microalbuminuria (41.8 microg/min) at baseline, which decreased to a value of 3.1 microg/min (classified as normoalbuminuria) at 1 year. This study provides preliminary evidence that long-term weight loss with a very-low-carbohydrate diet does not adversely affect renal function compared with a high-carbohydrate diet in obese individuals with normal renal function. |
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Authors:
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Grant D Brinkworth; Jonathan D Buckley; Manny Noakes; Peter M Clifton |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Dietetic Association Volume: 110 ISSN: 1878-3570 ISO Abbreviation: J Am Diet Assoc Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503061 Medline TA: J Am Diet Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 633-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Commonwealth Scientific and Industrial Research Organisation - Human Nutrition, PO Box 10041 BC, Adelaide, South Australia 5000. grant.brinkworth@csiro.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuminuria / epidemiology Analysis of Variance Creatinine / blood Diet, Carbohydrate-Restricted Diet, Fat-Restricted Dietary Carbohydrates / administration & dosage*, metabolism Dietary Fats / administration & dosage*, metabolism Dietary Proteins / administration & dosage, adverse effects*, metabolism Dose-Response Relationship, Drug Female Glomerular Filtration Rate / drug effects, physiology Humans Kidney / drug effects*, physiology Male Middle Aged Obesity, Abdominal / diet therapy* Patient Compliance Treatment Outcome Weight Loss* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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