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Renal Epithelial Sodium Channel (ENaC) is Critical for Blood Pressure Maintenance and Sodium Balance in the Normal Late Pregnant Rat.
MedLine Citation:
PMID:  24563165     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Normal pregnancy is a state marked by avid Na retention and plasma volume expansion (PVE). Insufficient PVE results in the compromised maternal state of intrauterine growth restriction which afflicts ~5% of all pregnancies. We have recently shown that renal in vivo epithelial sodium channel (ENaC) activity in the late pregnant (LP) rat is increased. To determine the importance of renal vs extrarenal ENaC in sodium retention and blood pressure regulation during pregnancy, we have chronically blocked ENaC pharmacologically with daily subcutaneous injections of benzamil (BZ) and genetically using intrarenal transfection of αENaC shRNA. Compared with untreated LP controls (CON), LP rats with BZ (ChBz), retain less sodium and have reduced mean arterial pressures (MAP). Further, LP rats with BZ had lower maternal body weight gains (ΔBW). Intrarenal transfection of αENaC shRNA vs scrambled sRNA successfully decreased renal αENaC mRNA expression in LP rats. Intrarenal transfection of αENaC shRNA reduced maternal sodium retention, ΔBW, and pup weight. Redundant physiological systems which protect blood pressure and sodium homeostasis were unable to compensate for the loss of ENaC activity in the pregnant rat. These findings demonstrate that renal ENaC is necessary for maintaining pregnancy-mediated sodium retention, volume expansion and blood pressure regulation.
Authors:
Crystal A West; Weiquing Han; Ning-Jun Li; Shyama Me Masilamani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-21
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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