Document Detail

Removing pathogenic memories: a neurobiology of psychotherapy.
MedLine Citation:
PMID:  16215277     Owner:  NLM     Status:  MEDLINE    
Experimental research examining the neural bases of nondeclarative memory has offered intriguing insight into how functional and dysfunctional implicit learning affects the brain. Long-term modifications of synaptic transmission, in particular, are currently considered the most plausible mechanism underlying memory trace encoding and compulsions, addiction, anxiety, and phobias. Therefore, an effective psychotherapy must be directed to erase maladaptive implicit memories and aberrant synaptic plasticity. This article describes the neurobiological bases of pathogenic memory disruption to provide some insight into how psychotherapy works. At least two mechanisms of unwanted memory erasing appear to be implicated in the effects of psychotherapy: inhibition of memory consolidation/reconsolidation and extinction. Behavioral evidence demonstrated that these two ways to forget are profoundly distinct in nature, and it is increasingly clear that their cellular, synaptic, and molecular underpinnings are different. Accordingly, the blockade of consolidation/reconsolidation erases memories by reversing the plasticity associated with memory maintenance, whereas extinction is a totally new form of plasticity that, similar to the plasticity underlying the old memory, requires protein synthesis-dependent synaptic remodeling.
Diego Centonze; Alberto Siracusano; Paolo Calabresi; Giorgio Bernardi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular neurobiology     Volume:  32     ISSN:  0893-7648     ISO Abbreviation:  Mol. Neurobiol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-10     Completed Date:  2007-06-12     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8900963     Medline TA:  Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-32     Citation Subset:  IM    
Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy.
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MeSH Terms
Long-Term Potentiation / physiology
Memory / physiology*
Synapses / metabolism
Synaptic Transmission / physiology

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