Document Detail

Removing the effects of CSF partial voluming on fitted CBF and arterial transit times using FAIR, a pulsed arterial spin labelling technique.
MedLine Citation:
PMID:  16763807     Owner:  NLM     Status:  MEDLINE    
FAIR, an arterial spin labelling technique, provides non-invasive, quantitative CBF values and arterial transit times deltat. This paper focuses on the negative impact of CSF partial voluming on FAIR results. To understand and solve this problem, we performed a theoretical analysis and a range of simulations. We then acquired FAIR data from a volunteer to illustrate our findings. We found that the determinant effect of CSF is a delayed zero-crossing during inversion recovery. The subtraction of magnitude inversion recovery data in FAIR generates erroneous negative data and distorted fit results: we simulated that for CSF percentages of 0-40%, CBF and deltat will be progressively overestimated by up to 50%. For higher CSF percentages the errors were found to increase steeply. We explored a straightforward solution: taking the magnitude of the FAIR data before fitting. This provided a remarkably strong antidote against the effects of CSF partial voluming: for CSF percentages of 0-40%, simulations now gave CBF values accurate within 1%, and deltat within 5%. The fit remained robust for high CSF fractions. Our analysis and simulations demonstrate that using magnitude FAIR data minimises the detrimental effects of CSF partial voluming. Data from a healthy volunteer illustrate these results.
J Wiersma; R Deichmann; R Ordidge; R Turner
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-09
Journal Detail:
Title:  Magma (New York, N.Y.)     Volume:  19     ISSN:  0968-5243     ISO Abbreviation:  MAGMA     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-10-25     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  9310752     Medline TA:  MAGMA     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK.
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MeSH Terms
Blood Flow Velocity / physiology
Brain / anatomy & histology,  blood supply*,  physiology*
Cerebral Arteries / anatomy & histology,  physiology
Cerebrospinal Fluid*
Cerebrovascular Circulation / physiology
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging / instrumentation,  methods*
Phantoms, Imaging
Spin Labels
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Spin Labels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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