Document Detail


Removing brakes on adult brain plasticity: from molecular to behavioral interventions.
MedLine Citation:
PMID:  21068299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult brain plasticity, although possible, remains more restricted in scope than during development. Here, we address conditions under which circuit rewiring may be facilitated in the mature brain. At a cellular and molecular level, adult plasticity is actively limited. Some of these "brakes" are structural, such as perineuronal nets or myelin, which inhibit neurite outgrowth. Others are functional, acting directly upon excitatory-inhibitory balance within local circuits. Plasticity in adulthood can be induced either by lifting these brakes through invasive interventions or by exploiting endogenous permissive factors, such as neuromodulators. Using the amblyopic visual system as a model, we discuss genetic, pharmacological, and environmental removal of brakes to enable recovery of vision in adult rodents. Although these mechanisms remain largely uncharted in the human, we consider how they may provide a biological foundation for the remarkable increase in plasticity after action video game play by amblyopic subjects.
Authors:
Daphne Bavelier; Dennis M Levi; Roger W Li; Yang Dan; Takao K Hensch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  30     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2010-12-13     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14964-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiology*
Critical Period (Psychology)
Humans
Neuronal Plasticity / physiology*
Neurons / physiology*
Synapses / physiology*
Grant Support
ID/Acronym/Agency:
EY016880/EY/NEI NIH HHS; EY18861/EY/NEI NIH HHS; EYRO10178//PHS HHS; R01 EY001728/EY/NEI NIH HHS; R01 EY001728-35/EY/NEI NIH HHS; R01 EY016880/EY/NEI NIH HHS; R01 EY016880-05/EY/NEI NIH HHS; R01 EY018861/EY/NEI NIH HHS; R01 EY018861-04/EY/NEI NIH HHS; R01 EY020976/EY/NEI NIH HHS; R01 EY020976-01/EY/NEI NIH HHS; R01EY020976/EY/NEI NIH HHS
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