| Removed antibiotic-impregnated cement spacers in two-stage revision joint arthroplasty do not show biofilm formation in vivo. | |
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MedLine Citation:
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PMID: 23146367 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Use of antibiotic-impregnated spacers is common in the two-stage approach to treatment of periprosthetic joint infection despite the lack of information regarding in vivo performance of these implants. Antibiotic elution levels likely often fall below the minimal inhibitory concentration need to inhibit bacterial growth, raising concern that the spacers themselves may provide a potential attachment site for biofilm formation. Advanced microscopy was used in this study to evaluate the surface characteristics of antibiotic-eluting spacers collected at the time of prosthesis reimplantation from 6 patients undergoing two-stage treatment for an infected total joint arthroplasty. Scanning electron microscopy and confocal scanning microscopy of the removed spacers revealed modest fibrous matrix formation and inflammatory cells with no biofilm or bacteria detected. This study supports the continued use of antibiotic spacers in the treatment of periprosthetic joint infection. |
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Authors:
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Justin W Griffin; Stacey J Guillot; Jan A Redick; James A Browne |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of arthroplasty Volume: 27 ISSN: 1532-8406 ISO Abbreviation: J Arthroplasty Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703515 Medline TA: J Arthroplasty Country: United States |
Other Details:
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Languages: eng Pagination: 1796-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, Virginia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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