Document Detail

Removed antibiotic-impregnated cement spacers in two-stage revision joint arthroplasty do not show biofilm formation in vivo.
MedLine Citation:
PMID:  23146367     Owner:  NLM     Status:  In-Data-Review    
Use of antibiotic-impregnated spacers is common in the two-stage approach to treatment of periprosthetic joint infection despite the lack of information regarding in vivo performance of these implants. Antibiotic elution levels likely often fall below the minimal inhibitory concentration need to inhibit bacterial growth, raising concern that the spacers themselves may provide a potential attachment site for biofilm formation. Advanced microscopy was used in this study to evaluate the surface characteristics of antibiotic-eluting spacers collected at the time of prosthesis reimplantation from 6 patients undergoing two-stage treatment for an infected total joint arthroplasty. Scanning electron microscopy and confocal scanning microscopy of the removed spacers revealed modest fibrous matrix formation and inflammatory cells with no biofilm or bacteria detected. This study supports the continued use of antibiotic spacers in the treatment of periprosthetic joint infection.
Justin W Griffin; Stacey J Guillot; Jan A Redick; James A Browne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of arthroplasty     Volume:  27     ISSN:  1532-8406     ISO Abbreviation:  J Arthroplasty     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703515     Medline TA:  J Arthroplasty     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1796-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Orthopaedic Surgery, University of Virginia Health System, Charlottesville, Virginia.
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