Document Detail

Removal of microsatellite interruptions by DNA replication slippage: phylogenetic evidence from Drosophila.
MedLine Citation:
PMID:  10889213     Owner:  NLM     Status:  MEDLINE    
Microsatellites are tandem repetitions of short (1-6 bp) motifs. It is widely assumed that microsatellites degenerate through the accumulation of base substitutions in the repeat array. Using a phylogenetic framework, we studied the evolutionary dynamics of interruptions in three Drosophila microsatellite loci. For all three loci, we show that the interruptions in a microsatellite can be lost, resulting in a longer uninterrupted microsatellite stretch. These results indicate that mutations in the microsatellite array do not necessarily lead to decay but may represent only a transition state during the evolution of a microsatellite. Most likely, this purification of interrupted microsatellites is caused by DNA replication slippage.
B Harr; B Zangerl; C Schlötterer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular biology and evolution     Volume:  17     ISSN:  0737-4038     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-09     Completed Date:  2000-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1001-9     Citation Subset:  IM    
Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Austria.
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MeSH Terms
Base Sequence
DNA Replication*
Drosophila / genetics*
Molecular Sequence Data
Sequence Homology, Nucleic Acid
Species Specificity
Reg. No./Substance:

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