Document Detail


Remote pharmacological preconditioning on median nerve territory increases Hsp32 expression and attenuates ischemia-reperfusion injury in rat heart.
MedLine Citation:
PMID:  22369754     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: The aim of this study was to test the hypothesis that remote pharmacological preconditioning (RPP) induced myocardial heat shock protein (Hsp) 32 expression and attenuated the ischemia-reperfusion (I/R) injury of the heart in rats. MAIN METHODS: Animals were injected at the left median nerve territory with chloralose and urethane mixture. At different time intervals, myocardial Hsp32 gene expression was analyzed. Primary heart cultures were used to investigate the direct effect of drug mixture on Hsp32 expression. KEY FINDINGS: The results showed that Hsp32 was time- and dose-dependently increased by in vivo drug mixture treatment, but not in primary cultures. RPP significantly decreased the duration of arrhythmia and incidence of stony heart in rats with subsequent I/R injury. SIGNIFICANCE: We conclude that RPP on the left median nerve territory induced Hsp32 gene expression in the heart and attenuates myocardial damage functionally after subsequent I/R injury.
Authors:
Jen-Hwey Chiu; Ya-Fang Cheng; Jir-You Wang; Cheng-Fong Hsu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-17
Journal Detail:
Title:  Life sciences     Volume:  -     ISSN:  1879-0631     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taiwan, ROC; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taiwan, ROC; Division of General Surgery, Department of Surgery, Cheng-Hsiun Hospital, Taipei, Taiwan, ROC.
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