Document Detail


Remote ischemic preconditioning in major vascular surgery.
MedLine Citation:
PMID:  18829224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Remote ischemic preconditioning is a physiologic mechanism in mammalian species whereby brief exposure to nonlethal ischemia in one tissue confers protection against a prolonged ischemic insult in a distant tissue. First described almost 15 years ago, it has been slow to translate into clinical practice. Several clinical trials have recently reported that remote ischemic preconditioning reduces myocardial injury after major cardiovascular surgery. In addition, a randomized trial in patients undergoing open abdominal aortic aneurysm repair reported a significant reduction in perioperative myocardial infarctions. Remote ischemic preconditioning is easily performed and likely to prove highly cost-effective. large-scale trials of the technique are warranted in patients undergoing major vascular surgery.
Authors:
Stewart R Walsh; Tjun Y Tang; Umar Sadat; Michael E Gaunt
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-10-01
Journal Detail:
Title:  Journal of vascular surgery     Volume:  49     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-02-19     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-3     Citation Subset:  IM    
Affiliation:
Cambridge Vascular Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Aneurysm, Abdominal / surgery
Humans
Ischemic Preconditioning*
Ischemic Preconditioning, Myocardial
Myocardial Infarction / etiology,  prevention & control
Myocardial Reperfusion Injury / etiology,  prevention & control
Reperfusion Injury / etiology,  metabolism,  prevention & control*
Signal Transduction
Treatment Outcome
Vascular Surgical Procedures / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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