| Remote ischemic preconditioning in major vascular surgery. | |
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MedLine Citation:
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PMID: 18829224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Remote ischemic preconditioning is a physiologic mechanism in mammalian species whereby brief exposure to nonlethal ischemia in one tissue confers protection against a prolonged ischemic insult in a distant tissue. First described almost 15 years ago, it has been slow to translate into clinical practice. Several clinical trials have recently reported that remote ischemic preconditioning reduces myocardial injury after major cardiovascular surgery. In addition, a randomized trial in patients undergoing open abdominal aortic aneurysm repair reported a significant reduction in perioperative myocardial infarctions. Remote ischemic preconditioning is easily performed and likely to prove highly cost-effective. large-scale trials of the technique are warranted in patients undergoing major vascular surgery. |
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Authors:
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Stewart R Walsh; Tjun Y Tang; Umar Sadat; Michael E Gaunt |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-10-01 |
Journal Detail:
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Title: Journal of vascular surgery Volume: 49 ISSN: 1097-6809 ISO Abbreviation: J. Vasc. Surg. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-28 Completed Date: 2009-02-19 Revised Date: 2012-10-03 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 240-3 Citation Subset: IM |
Affiliation:
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Cambridge Vascular Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Aneurysm, Abdominal / surgery Humans Ischemic Preconditioning* Ischemic Preconditioning, Myocardial Myocardial Infarction / etiology, prevention & control Myocardial Reperfusion Injury / etiology, prevention & control Reperfusion Injury / etiology, metabolism, prevention & control* Signal Transduction Treatment Outcome Vascular Surgical Procedures / adverse effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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