Document Detail


Remote ischemic preconditioning and endothelial function in patients with acute myocardial infarction and primary PCI.
MedLine Citation:
PMID:  24565591     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Remote ischemic preconditioning (RIPC) by transient limb ischemia reduces myocardial ischemia-reperfusion injury in patients undergoing percutaneous coronary intervention (PCI). The aim of study we report here was to assess the effect of RIPC on endothelial function in patients with acute myocardial infarction (AMI) who underwent primary PCI.
METHODS: Forty eight patients withAMI were enrolled. All participants were randomly divided into two groups. In Group I (n = 23), RIPC was performed prior to primary PCI (intermittent arm ischemia-reperfusion through four cycles of 5-min inflation and 5-min deflation of a blood-pressure cuff to 200 mm Hg). In Group II (n = 25), standard PCI without preconditioning was performed. We assessed endothelial function using the flow-mediated dilation (FMD) test on baseline, then within 1-3 hours after PCI, and again on days 2 and 7 after PCI.
RESULTS: The brachial artery FMD results were significantly higher on the first day after primary PCI in the preconditioning group (Group I) than in the control group (Group II) (12.1% vs. 0.0%, p=0.03, and 11.1% vs. 6.3%, p=0.016, respectively), and this difference remained on the seventh day (12.3% vs. 7.4%, p=0.0005, respectively).
CONCLUSION: We demonstrated for the first time that remote ischemic preconditioning prior to primary PCI significantly improves endothelial function in patients with AMI and this effect remains constantat least for a week. We suppose that the improvement of endothelial function may be one of the possible explanations of the effect of RIPC.
Authors:
Vladimir Manchurov; Nadezda Ryazankina; Tatyana Khmara; Dmitry Skrypnik; Roman Reztsov; Elena Vasilieva; Alexander Shpektor
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-21
Journal Detail:
Title:  The American journal of medicine     Volume:  -     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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