| Remote ischemic precondition preserves cerebral oxygen tension during hypothermic circulatory arrest. | |
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MedLine Citation:
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PMID: 22288607 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objectives: Remote ischemic preconditioning is a novel and promising method of mitigating neurological injury. In previous animal studies, remote ischemic preconditioning has provided substantial neuroprotective effects. We hypothesized that the promising neuroprotective properties were a consequence of a better oxygen consumption profile during hypothermic circulatory arrest. Design: Six 7-week-old female pigs were randomly assigned to undergo the 60 minutes of hypothermic circulatory arrest with the right hind leg receiving transient remote ischemic preconditioning preoperatively and six animals were assigned to a control group that underwent 60 minutes of hypothermic circulatory arrest without any preconditioning. A combined temperature/oxygen-tension probe was inserted into the parietal cortex of each animal to monitor cerebral oxygen tension during experiments. Results: The remote ischemic preconditioning group had significantly higher cerebral oxygen tension readings throughout the hypothermic circulatory arrest. Statistically significant differences were measured from the 20 minute time point onwards in every time point up to the 60 minute time point. Conclusions: This study shows that remote ischemic preconditioning performed before hypothermic circulatory arrest conserves the cerebral oxygen tension during a circulatory arrest. Remote ischemic preconditioning could possibly prolong the safe operating time during hypothermic circulatory arrest as cerebral oxygen content is preserved throughout circulatory arrest. |
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Authors:
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Fredrik Yannopoulos; Tuomas Mäkelä; Oiva Arvola; Henri Haapanen; Vesa Anttila; Kai Kiviluoma; Tatu Juvonen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-30 |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: - ISSN: 1651-2006 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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