Document Detail

Remote ischaemic preconditioning: underlying mechanisms and clinical application.
MedLine Citation:
PMID:  18456674     Owner:  NLM     Status:  MEDLINE    
Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's endogenous protective capabilities against the injury incurred by ischaemia and reperfusion. It describes the intriguing phenomenon in which transient non-lethal ischaemia and reperfusion of one organ or tissue confers resistance to a subsequent episode of lethal ischaemia reperfusion injury in a remote organ or tissue. In its original conception, it described intramyocardial protection, which could be relayed from the myocardium served by one coronary artery to another. It soon became apparent that myocardial infarct size could be dramatically reduced by applying brief ischaemia and reperfusion to an organ or tissue remote from the heart before the onset of myocardial infarction. The concept of remote organ protection has now been extended beyond that of solely protecting the heart to providing a general form of inter-organ protection against ischaemia-reperfusion injury. This article reviews the history and evolution of the phenomenon that is RIPC, the potential mechanistic pathways underlying its cardioprotective effect, and its emerging application in the clinical setting.
Derek J Hausenloy; Derek M Yellon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-02
Journal Detail:
Title:  Cardiovascular research     Volume:  79     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-30     Completed Date:  2008-12-02     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  377-86     Citation Subset:  IM    
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MeSH Terms
Ischemic Preconditioning*
Ischemic Preconditioning, Myocardial
Myocardial Infarction / metabolism,  prevention & control*
Myocardial Reperfusion Injury / metabolism,  prevention & control
Myocardium / metabolism*
Reperfusion Injury / metabolism,  prevention & control*
Signal Transduction*
Treatment Outcome
Grant Support
RG/08/015/26411//British Heart Foundation; //British Heart Foundation; //Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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