| Remote ischaemic preconditioning: underlying mechanisms and clinical application. | |
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MedLine Citation:
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PMID: 18456674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's endogenous protective capabilities against the injury incurred by ischaemia and reperfusion. It describes the intriguing phenomenon in which transient non-lethal ischaemia and reperfusion of one organ or tissue confers resistance to a subsequent episode of lethal ischaemia reperfusion injury in a remote organ or tissue. In its original conception, it described intramyocardial protection, which could be relayed from the myocardium served by one coronary artery to another. It soon became apparent that myocardial infarct size could be dramatically reduced by applying brief ischaemia and reperfusion to an organ or tissue remote from the heart before the onset of myocardial infarction. The concept of remote organ protection has now been extended beyond that of solely protecting the heart to providing a general form of inter-organ protection against ischaemia-reperfusion injury. This article reviews the history and evolution of the phenomenon that is RIPC, the potential mechanistic pathways underlying its cardioprotective effect, and its emerging application in the clinical setting. |
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Authors:
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Derek J Hausenloy; Derek M Yellon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-05-02 |
Journal Detail:
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Title: Cardiovascular research Volume: 79 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-30 Completed Date: 2008-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 377-86 Citation Subset: IM |
Affiliation:
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The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, UK. d.hausenloy@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Ischemic Preconditioning* Ischemic Preconditioning, Myocardial Myocardial Infarction / metabolism, prevention & control* Myocardial Reperfusion Injury / metabolism, prevention & control Myocardium / metabolism* Reperfusion Injury / metabolism, prevention & control* Signal Transduction* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Department of Health |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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