Document Detail


Remote ischaemic preconditioning: underlying mechanisms and clinical application.
MedLine Citation:
PMID:  18456674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's endogenous protective capabilities against the injury incurred by ischaemia and reperfusion. It describes the intriguing phenomenon in which transient non-lethal ischaemia and reperfusion of one organ or tissue confers resistance to a subsequent episode of lethal ischaemia reperfusion injury in a remote organ or tissue. In its original conception, it described intramyocardial protection, which could be relayed from the myocardium served by one coronary artery to another. It soon became apparent that myocardial infarct size could be dramatically reduced by applying brief ischaemia and reperfusion to an organ or tissue remote from the heart before the onset of myocardial infarction. The concept of remote organ protection has now been extended beyond that of solely protecting the heart to providing a general form of inter-organ protection against ischaemia-reperfusion injury. This article reviews the history and evolution of the phenomenon that is RIPC, the potential mechanistic pathways underlying its cardioprotective effect, and its emerging application in the clinical setting.
Authors:
Derek J Hausenloy; Derek M Yellon
Related Documents :
6271994 - Studies on the na+-k+-atpase in myocardial infarction.
2000974 - Myocardial protection is lost before contractile function recovers from ischemic precon...
11273734 - Targeted deletion of the a3 adenosine receptor confers resistance to myocardial ischemi...
11871784 - Effects of brief ischaemia on myocardial acetylcholine and noradrenaline levels in anae...
21934524 - The left ventricle as a mechanical engine: from leonardo da vinci to the echocardiograp...
22026984 - Evaluation of left ventricular volumes and ejection fraction by gated myocardial perfus...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-02
Journal Detail:
Title:  Cardiovascular research     Volume:  79     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-30     Completed Date:  2008-12-02     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  377-86     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Ischemic Preconditioning*
Ischemic Preconditioning, Myocardial
Myocardial Infarction / metabolism,  prevention & control*
Myocardial Reperfusion Injury / metabolism,  prevention & control
Myocardium / metabolism*
Reperfusion Injury / metabolism,  prevention & control*
Signal Transduction*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
RG/08/015/26411//British Heart Foundation; //British Heart Foundation; //Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries.
Next Document:  ECG and heart rate variability changes in preterm and near-term fetal lamb following LPS exposure.