Document Detail


Remote Stereocontrol in [3,3]-Sigmatropic Rearrangements: Application to the Total Synthesis of the Immunosuppressant Mycestericin G.
MedLine Citation:
PMID:  22239476     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The Ireland-Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β'-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote stereocontrol. This strategy has been used to synthesize the natural immunosuppressant mycestericin G and ent-mycestericin G, allowing for a revision of absolute configuration of this natural product.
Authors:
Nathan W G Fairhurst; Mary F Mahon; Rachel H Munday; David R Carbery
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom, and AstraZeneca R&D, Charnwood, Bakewell Road, Loughborough LE11 5RH, United Kingdom.
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