| Remote-Conditioning Ischemia Provides a Potential Approach to Mitigate Contrast Medium-Induced Reduction in Kidney Function: A Retrospective Observational Cohort Study. | |
| | |
MedLine Citation:
|
PMID: 21952203 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Contrast medium administration during imaging and therapeutic procedures can cause renal injury, partly due to ischemia. Therefore, we hypothesized that brief ischemia and reperfusion episodes applied at a distant site - multiple balloon inflations and deflations during angioplasty - may serve as a remote-conditioning (RC) stimulus and thereby protect against contrast-induced kidney injury. To test this hypothesis, we (1) utilized cases from a prior study in which patients undergoing emergent angioplasty for ST segment elevation myocardial infarction received either 1-3 balloon inflations (controls) or were 'conditioned' with multiple (≥4) inflations, and (2) assessed renal function for 3 days in patients with an estimated glomerular filtration rate (eGFR) of <90 ml/min/1.73 m(2) prior to revascularization (mild kidney disease). Both groups displayed increased eGFR at day 1 after angioplasty versus baseline; attributed to in-hospital hydration (control: 77 ± 14 vs. 68 ± 12 ml/min/1.73 m(2); p < 0.01; RC: 81 ± 21 vs. 69 ± 12 ml/min/1.73 m(2); p < 0.01). In controls, this improvement was transient: eGFR subsequently decreased to 70 ± 14 ml/min/1.73 m(2) at day 3 (p < 0.05). In contrast, the RC group (despite receiving 25% more contrast volume) showed no functional decline at day 3 (80 ± 14 ml/min/1.73 m(2)). These results are consistent with remote ischemic conditioning providing a novel potential approach to attenuate contrast-associated renal injury. |
| | |
Authors:
|
Peter Whittaker; Karin Przyklenk |
Related Documents
:
|
21819483 - Beneficial effects of ankaferd blood stopper on caustic esophageal injuries: an experim... 21072223 - Clinical case report on treatment of generalized aggressive periodontitis. 21351853 - Pharmacoeconomics of dabigatran etexilate for prevention of thromboembolism after joint... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-23 |
Journal Detail:
|
Title: Cardiology Volume: 119 ISSN: 1421-9751 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1266406 Medline TA: Cardiology Country: - |
Other Details:
|
Languages: ENG Pagination: 145-150 Citation Subset: - |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Department of Emergency Medicine, Wayne State University, Detroit, Mich., USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Photoreactive gold(i) macrocycles with diphosphine and trans,trans-muconate ligands.
Next Document: Initiation of chromosomal DNA replication in eukaryotic cells; contribution of yeast genetics to the...