Document Detail

Remodelling of the left anterior descending artery in a porcine model of supravalvular aortic stenosis.
MedLine Citation:
PMID:  12473868     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Knowledge of the adaptive mechanisms of structure and function of coronary arteries in response to physical stress is important in human health and disease. OBJECTIVE: To gain a better understanding of the adaptive mechanisms of morphology in the zero-stress state of the coronary arteries in a porcine model of hypertension and flow overload. METHODS: The effects of simultaneous increases in pressure and flow were examined by studying the left anterior decending (LAD) artery in supravalvular aortic stenosis (SVAS). In this model, the pressure is uniformly increased along the length of the LAD artery trunk, whereas the increase in flow is significantly greater in the proximal than in the distal artery. The longitudinal variation of vessel dimension, medial and adventitial area, opening angle and residual strains were examined in the LAD arteries of aortic-banded (n = 5) and control (n = 5) pigs. RESULTS: Our results show that the wall shear stress was normalized, whereas the circumferential stress was increased, in the proximal portion of the LAD artery after 5 weeks of SVAS. In the distal artery, both shear and circumferential stresses were normalized. The vessel wall area was also increased in the remodelled vessels as the result of an increase in the medial and adventitial area. CONCLUSION: The major conclusion of this study is that, in the SVAS model, the remodelling process of the coronary artery is consistent with normalization of shear stress despite an increase in the circumferential stress. Furthermore, the remodelling of the zero-stress state is also dominated by flow overload.
Ghassan S Kassab; Hans Gregersen; Sten L Nielsen; Xiao Lu; Laszlo B Tanko; Erling Falk
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  20     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-10     Completed Date:  2003-06-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2429-37     Citation Subset:  IM    
Department of Biomedical Engineering, University of California, Irvine 92697, USA.
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MeSH Terms
Adaptation, Physiological*
Aortic Stenosis, Supravalvular / physiopathology*
Arteries / physiopathology
Coronary Vessels / physiopathology*
Models, Cardiovascular
Regional Blood Flow
Stress, Mechanical
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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