Document Detail


Remodeling of myocardial sleeve and gap junctions in canine superior vena cava after rapid pacing.
MedLine Citation:
PMID:  16568251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We studied the response of the superior vena cava (SVC) myocardial sleeve to atrial fibrillation (AF). METHODS AND RESULTS: We examined adult male dogs without pacing (N=6) and after rapid atrial pacing (600 bpm) for 2 weeks (P2w; N=5) and 6-8 weeks (P6-8w; N=5). After pacing, the sleeve was increased in thickness (non-paced vs. either paced group, both P<0.05). This was associated with an increase in proliferative activity, which was higher in the P2w than the P6-8w animals (P<0.05). In addition, collagen content increased, and the component cardiomyocytes become more unevenly oriented and shorter and narrower in shape (non-paced vs. either paced group, both P<0.05). Pacing had different effects on connexin40 (Cx40) and Cx43 gap junctions. There was a 98% increase in Cx43 signal in P2w, and a 74% increase in P6-8w animals (non-paced vs. each paced group, both P<0.05). In contrast, Cx40 signal decreased 47% in P2w but increased 44% in P6-8w animals (non-paced vs. each paced group, both P<0.05). CONCLUSIONS: Rapid atrial pacing results in a specific pattern of remodeling of the canine SVC sleeve, including changes in size and shape, spatial orientation, and gap junction expression profile of the component cardiomyocytes. These changes may co-operatively affect the electrical properties and contribute to the formation and maintenance of the arrhythmogenic substrate of AF.
Authors:
Hung-I Yeh; Yu-Jun Lai; Shih-Huang Lee; Sin-Tai Chen; Yu-Shien Ko; Shih-Ann Chen; Nicholas J Severs; Cheng-Ho Tsai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-27
Journal Detail:
Title:  Basic research in cardiology     Volume:  101     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-23     Completed Date:  2006-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  269-80     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Medical Research Mackay Memorial Hospital, Mackay Medicine Nursing and Management College, Taipei Medical University, 92, Sec 2, Chung San North Road, 10449, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Fibrillation / pathology*
Cardiac Pacing, Artificial
Cell Proliferation
Collagen / metabolism
Connexins / metabolism
Dogs
Gap Junctions / pathology*
Myocardium / pathology*
Myocytes, Cardiac / pathology*
Vena Cava, Superior / pathology*
Chemical
Reg. No./Substance:
0/Connexins; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  No loss of cardioprotection by postconditioning in connexin 43-deficient mice.
Next Document:  The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by F...