Document Detail

Remodeling of myocardial sleeve and gap junctions in canine superior vena cava after rapid pacing.
MedLine Citation:
PMID:  16568251     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We studied the response of the superior vena cava (SVC) myocardial sleeve to atrial fibrillation (AF). METHODS AND RESULTS: We examined adult male dogs without pacing (N=6) and after rapid atrial pacing (600 bpm) for 2 weeks (P2w; N=5) and 6-8 weeks (P6-8w; N=5). After pacing, the sleeve was increased in thickness (non-paced vs. either paced group, both P<0.05). This was associated with an increase in proliferative activity, which was higher in the P2w than the P6-8w animals (P<0.05). In addition, collagen content increased, and the component cardiomyocytes become more unevenly oriented and shorter and narrower in shape (non-paced vs. either paced group, both P<0.05). Pacing had different effects on connexin40 (Cx40) and Cx43 gap junctions. There was a 98% increase in Cx43 signal in P2w, and a 74% increase in P6-8w animals (non-paced vs. each paced group, both P<0.05). In contrast, Cx40 signal decreased 47% in P2w but increased 44% in P6-8w animals (non-paced vs. each paced group, both P<0.05). CONCLUSIONS: Rapid atrial pacing results in a specific pattern of remodeling of the canine SVC sleeve, including changes in size and shape, spatial orientation, and gap junction expression profile of the component cardiomyocytes. These changes may co-operatively affect the electrical properties and contribute to the formation and maintenance of the arrhythmogenic substrate of AF.
Hung-I Yeh; Yu-Jun Lai; Shih-Huang Lee; Sin-Tai Chen; Yu-Shien Ko; Shih-Ann Chen; Nicholas J Severs; Cheng-Ho Tsai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-27
Journal Detail:
Title:  Basic research in cardiology     Volume:  101     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-23     Completed Date:  2006-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  269-80     Citation Subset:  IM    
Department of Internal Medicine and Medical Research Mackay Memorial Hospital, Mackay Medicine Nursing and Management College, Taipei Medical University, 92, Sec 2, Chung San North Road, 10449, Taipei, Taiwan.
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MeSH Terms
Atrial Fibrillation / pathology*
Cardiac Pacing, Artificial
Cell Proliferation
Collagen / metabolism
Connexins / metabolism
Gap Junctions / pathology*
Myocardium / pathology*
Myocytes, Cardiac / pathology*
Vena Cava, Superior / pathology*
Reg. No./Substance:
0/Connexins; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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