| Remodeling of the left ventricle in primary aldosteronism due to Conn's adenoma. | |
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MedLine Citation:
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PMID: 9118515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Since hyperaldosteronism has been experimentally related to myocardial interstitial fibrosis, we investigated the effects of hypertension and excess aldosterone due to aldosterone-producing adenomas (APAs) on the heart. METHODS AND RESULTS: In 52 hypertensive individuals, we performed Doppler echocardiography for estimation of left ventricular (LV) wall thickness and dimensions, transmitral LV filling flow velocity indexes, and 24-hour ambulatory blood pressure monitoring. Consecutive patients with APAs (n = 26) and essential hypertension (EH, n = 26) were individually matched for age, sex, race, body mass index, casual blood pressure, and known duration of hypertension. The matched groups were similar for demography, casual and 24-hour blood pressure values and variability, and duration of hypertension but differed for serum potassium, plasma renin activity, and aldosterone levels (all P < .001). A thicker interventricular septum (P = .015) and posterior wall (P = .009) and a higher LV mass index (118 +/- 5 versus 100 +/- 4 g/m2, P = .009) were observed in APA compared with EH patients. Both septum and posterior wall thicknesses had a significant direct relationship with age, plasma aldosterone, and mean blood pressure. The integral of the early diastolic filling wave (Ei) (P = .011) and the ratio Ei/Ai (A wave integral) (P = .038) were lower and the atrial contribution to LV filling was higher (52 +/- 2% versus 46 +/- 2%, P = .038) in APA than in EH patients. The ratio Ei/Ai was significantly (P = .008) inversely related only to age and plasma aldosterone. CONCLUSIONS: In APA patients, the excess aldosterone is associated with both increased LV wall thickness and mass and decreased early diastolic LV filling indexes compared with demographically similar EH with superimposable blood pressure values, profile, and variability. |
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Authors:
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G P Rossi; A Sacchetto; E Pavan; P Palatini; G R Graniero; C Canali; A C Pessina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 95 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-04-24 Completed Date: 1997-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1471-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical and Experimental Medicine, University of Padua Medical School, Italy. gprossi@ipdunidx.unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications*,
secretion* Adrenal Gland Neoplasms / complications*, secretion Adult Aged Aldosterone / secretion Blood Flow Velocity Coronary Circulation Diastole Echocardiography* Female Heart Ventricles Humans Hyperaldosteronism / etiology*, physiopathology, ultrasonography* Hypertension / complications Male Middle Aged Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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