Document Detail


Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy.
MedLine Citation:
PMID:  24460198     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract Arrhythmogenic cardiomyopathy (AC) is a primary myocardial disorder characterized by a high incidence of ventricular arrhythmias often preceding the onset of ventricular remodeling and dysfunction. Approximately 50% of patients diagnosed with AC have one or more mutations in genes encoding desmosomal proteins, although non-desmosomal genes have also been associated with the disease. Increasing evidence implicates remodeling of intercalated disk proteins reflecting abnormal responses to mechanical load and aberrant cell signaling pathways in the pathogenesis of AC. This review summarizes recent advances in understanding disease mechanisms in AC that have come from studies of human myocardium and experimental models.
Authors:
Angeliki Asimaki; Jeffrey E Saffitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell communication & adhesion     Volume:  21     ISSN:  1543-5180     ISO Abbreviation:  Cell Commun. Adhes.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-01-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101096596     Medline TA:  Cell Commun Adhes     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-23     Citation Subset:  IM    
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