| Remodeling of calcium handling in human heart failure. | |
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MedLine Citation:
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PMID: 22453987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart failure (HF) is an increasing public health problem accelerated by a rapidly aging global population. Despite considerable progress in managing the disease, the development of new therapies for effective treatment of HF remains a challenge. To identify targets for early diagnosis and therapeutic intervention, it is essential to understand the molecular and cellular basis of calcium handling and the signaling pathways governing the functional remodeling associated with HF in humans. Calcium (Ca(2+)) cycling is an essential mediator of cardiac contractile function, and remodeling of calcium handling is thought to be one of the major factors contributing to the mechanical and electrical dysfunction observed in HF. Active research in this field aims to bridge the gap between basic research and effective clinical treatments of HF. This chapter reviews the most relevant studies of calcium remodeling in failing human hearts and discusses their connections to current and emerging clinical therapies for HF patients. |
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Authors:
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Qing Lou; Ajit Janardhan; Igor R Efimov |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 740 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-28 Completed Date: 2012-09-18 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1145-74 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Washington University in St. Louis, 390E Whitaker Hall, One Brookings Drive, St. Louis, MO 63130, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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etiology Calcium / metabolism* Calcium Signaling Heart Failure / metabolism* Humans Myocardium / metabolism* Ryanodine Receptor Calcium Release Channel / physiology Sarcoplasmic Reticulum Calcium-Transporting ATPases / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL114395/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ryanodine Receptor Calcium Release Channel; 7440-70-2/Calcium; EC 3.6.3.8/Sarcoplasmic Reticulum Calcium-Transporting ATPases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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