| Remnant lipoprotein cholesterol homogenous assay (RemL-C) is closely associated with very-low-density lipoprotein remnants: comparison with the immunoseparation assay. | |
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MedLine Citation:
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PMID: 19086452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Remnant-like particle-cholesterol (RLP-C) is recognized as a risk factor for cardiovascular disease. As an alternative to the immunoseparation assay widely used for the measurement of RLP-C, a new remnant lipoprotein-C homogenous assay (RemL-C) is available. In light of its homogeneity as an assay method, we speculated that this homogeneous assay (RemL-C) is closely associated with very-low-density lipoprotein(VLDL) remnant including intermediate-density lipoprotein(IDL). We examined the characteristics of the homogeneous assay for reacting with VLDL remnants. METHODS AND RESULTS: VLDL1, VLDL2, and IDL were separated by ultracentrifugation in the fasting serum of subjects including hypertriglyceridemia and uremic patients usually having higher levels of remnants. While RemL-C and RLP-C were mainly recovered in VLDL1 and both assays were strongly correlated with serum TG and VLDL1, the RemL-C assay was more closely correlated with VLDL2 and IDL levels than the RLP-C assay. RemL-C levels were significantly correlated with IDL-C, whereas RLP-C levels had only borderline associations with IDL-C (r= 0.56 Vs. 0.31). CONCLUSIONS: The remnant lipoprotein cholesterol homogenous assay is more closely associated with VLDL2 and IDL than the immunoseparation assay. |
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Authors:
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Masaharu Nagashima; Yusaku Mori; Ryo Morita; Michiya Takada; Soushou Lee; Takayasu Taira; Kazuhito Miyauchi; Hideyuki Kuwata; Norihiko Kayahara; Tsutomu Hirano |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Rinsho byori. The Japanese journal of clinical pathology Volume: 56 ISSN: 0047-1860 ISO Abbreviation: Rinsho Byori Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-17 Completed Date: 2009-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984781R Medline TA: Rinsho Byori Country: Japan |
Other Details:
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Languages: eng Pagination: 973-9 Citation Subset: IM |
Affiliation:
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Department of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine, Shinagawa-ku, Tokyo 142-8666, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Cardiovascular Diseases / etiology Cholesterol / blood* Cholesterol, VLDL / blood* Humans Hyperlipidemias / blood Immunoassay / methods* Lipoproteins / blood* Middle Aged Renal Dialysis Risk Factors Triglycerides / blood* Uremia / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, VLDL; 0/Lipoproteins; 0/Triglycerides; 0/remnant-like particle cholesterol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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