Document Detail

Is remitting seronegative symmetrical synovitis with pitting edema (RS3PE) a subset of rheumatoid arthritis?
MedLine Citation:
PMID:  19217650     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To contrast and compare the spectrum of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) with rheumatoid arthritis (RA) using an illustrative case.
METHODS: The relevant English literature of RS3PE was searched using the keywords "RS3PE" alone and in combination with terms such as neoplasia and rheumatic disease. Original and review articles were reviewed and the clinical setting was exemplified with a case report.
RESULTS: RS3PE initially was reported to represent a form of RA. However, RS3PE has clinical features that are different from both early- and late-onset RA, such as lack of bony erosions and rheumatoid factor. RS3PE is thought to involve vascular endothelial growth factor, suggesting an infectious etiology, generally has an excellent prognosis, and is associated with neoplasia not commonly seen in RA, and the RA associated human leukocyte antigen (HLA) DRB1 genotype is absent.
CONCLUSIONS: Based on the clinical, laboratory, suspected infectious etiology, genetic differences, and types of associated malignancies, RS3PE appears to be a distinct entity rather than a subset of RA.
Qingping Yao; Xiangqian Su; Roy D Altman
Publication Detail:
Type:  Journal Article; Review     Date:  2009-02-13
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  40     ISSN:  1532-866X     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-11-09     Revised Date:  2011-02-23    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Division of Rheumatology and Immunology, Department of Medicine, David Geffen Medical School at UCLA, Los Angeles, CA 90095, USA.
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MeSH Terms
Arthritis, Rheumatoid / complications*,  diagnosis
Diagnosis, Differential
Edema* / diagnosis,  etiology,  immunology
Paraneoplastic Syndromes
Serologic Tests
Synovitis* / diagnosis,  etiology,  immunology
Vascular Endothelial Growth Factor A / immunology*
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A
Comment In:
Semin Arthritis Rheum. 2011 Feb;40(4):e1   [PMID:  21272737 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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