| Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate. | |
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MedLine Citation:
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PMID: 10074595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 46-year-old woman developed nephrotic syndrome secondary to rheumatoid arthritis (RA). A renal biopsy showed deposition of amyloid fibrils in the subendothelial space of the glomerular capillary walls. After treatment with prednisolone (PSL, 40 mg/day), the levels of C-reactive protein (CRP) and serum amyloid A decreased to within normal limits for 2 weeks. However, the nephrotic syndrome persisted for 6 months after the therapy. To maintain the suppression of disease activity and to reduce PSL, methotrexate (5 mg/week) was added. The nephrotic syndrome resolved gradually, and the level of serum albumin returned to normal. Although renal prognosis of patients with nephrotic syndrome due to amyloidosis caused by RA has been considered poor, adequate and long-term treatment of RA with antiinflammatory drugs, including PSL and methotrexate, is useful for patients with secondary amyloidosis complicated by RA. |
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Authors:
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A Komatsuda; K Morita; H Ohtani; A Yamaguchi; A B Miura |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 32 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Akita University School of Medicine, Akita, Japan. komatsud@med.akita-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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complications* Anti-Inflammatory Agents / therapeutic use* Arthritis, Rheumatoid / complications* Drug Therapy, Combination Female Humans Kidney Diseases / complications Methotrexate / therapeutic use* Middle Aged Nephrotic Syndrome / drug therapy*, etiology Prednisolone / therapeutic use* Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-24-8/Prednisolone; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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