| Remission of nephrotic syndrome after thalidomide therapy in a patient with Castleman's disease. | |
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MedLine Citation:
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PMID: 15182131 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Castleman's is an uncommon lymphoproliferative disorder secondary to lymphoid follicle hyperplasia and marked capillary proliferation with endothelial hyperplasia. This illness can be associated with glomerulonephritis (GN). Here, we report a case with steroid-dependent nephrotic syndrome secondary to proliferative mesangial glomerulonephritis in a patient with Castleman's disease, that was diagnosed several years before. Considering the involvement of IL-6 in Castleman's disease we treated the patient with thalidomide obtaining the remission of the nephrotic syndrome. Our experience suggests a possible role of thalidomide in the treatment of glomerular pathology when a role of IL-6 is hypothesized. |
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Authors:
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M Adorati Menegato; M Fanni Canelles; E Tonutti; S Pizzolitto |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical nephrology Volume: 61 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-06-08 Completed Date: 2005-03-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 352-6 Citation Subset: IM |
Affiliation:
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Nephrology and Dialysis Unit, Ospedale Sant Antonio, ASS 4 Medio Friuli, Italy. ndsd@ass4.sanita.fvg.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Female Giant Lymph Node Hyperplasia / complications* Glomerulonephritis, Membranoproliferative / complications*, drug therapy, pathology Humans Immunosuppressive Agents / therapeutic use* Kidney Glomerulus / pathology Nephrotic Syndrome / drug therapy*, etiology Thalidomide / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 50-35-1/Thalidomide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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