Document Detail

Remission of acromegaly after pituitary apoplexy: case report and review of literature.
MedLine Citation:
PMID:  19546053     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify and present cases of acromegaly in which pituitary apoplexy resulted in remission of acromegaly, with normalization of insulinlike growth factor-I and growth hormone levels. METHODS: We present a case history of a personal patient and review the related literature in PubMed and Ovid MEDLINE. RESULTS: A 34-year-old man with classic acromegaly had spontaneous pituitary apoplexy, resulting in remission of his acromegaly and diabetes. Moreover, we identified 21 other similar cases in the literature and analyze the clinical presentations, possible apoplexy triggers, and hormonal sequelae. All these patients were "cured" of acromegaly, and 68% of them experienced other pituitary hormone insufficiencies after pituitary apoplexy, including 2 cases of panhypopituitarism. CONCLUSION: Pituitary apoplexy can result in remission of acromegaly and in partial or complete anterior or posterior (or both) pituitary insufficiency. Thus, after suspected or confirmed pituitary apoplexy, pituitary hormone secretion must be reevaluated. This assessment may result in initiation of appropriate substitution therapy, a change in management of growth hormone overproduction, or both interventions.
Lisa-Ann Fraser; Donald Lee; Paul Cooper; Stan Van Uum
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  15     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2010-01-01     Completed Date:  2010-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  725-31     Citation Subset:  IM    
Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
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MeSH Terms
Acromegaly / diagnosis,  pathology*
Magnetic Resonance Imaging
Pituitary Apoplexy / diagnosis,  pathology*
Remission, Spontaneous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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