Document Detail

Remifentanil in paediatric anaesthetic practice.
MedLine Citation:
PMID:  19302645     Owner:  NLM     Status:  MEDLINE    
Remifentanil is a synthetic opioid, first introduced into clinical practice in 1996. Its unique pharmacokinetic profile has resulted in a gradual increase in its popularity in paediatric anaesthesia. It is an opioid of high potency and rapid clearance, consequently lacking problems of accumulation. These characteristics give it a high degree of predictability and it has become an attractive choice for a wide variety of anaesthetic challenges, from premature neonates to the elderly. Neonates and infants have a higher clearance than older children and, as a result, remifentanil has additional benefits in this group. Remifentanil can be described as the only consistently predictable opioid in paediatric practice.
D F Marsh; B Hodkinson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia     Volume:  64     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  AIM; IM    
Department of Anaesthesia, Queen Alexandra Hospital, Portsmouth, UK.
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MeSH Terms
Analgesics, Opioid / pharmacokinetics,  pharmacology*
Hemodynamics / drug effects
Infant, Newborn
Neurosurgical Procedures
Pain, Postoperative / prevention & control
Piperidines / pharmacokinetics,  pharmacology*
Respiratory System / drug effects
Reg. No./Substance:
0/Analgesics, Opioid; 0/Piperidines; 132875-61-7/remifentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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