| Remifentanil in critically ill cardiac patients. | |
| | |
MedLine Citation:
|
PMID: 21196668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Remifentanil has a unique pharmacokinetic profile, with a rapid onset and offset of action and a plasmatic metabolism. Its use can be recommended even in patients with renal impairment, hepatic dysfunction or poor cardiovascular function. A potential protective cardiac preconditioning effect has been suggested. Drug-related adverse effects seem to be comparable with other opioids. In cardiac surgery, many randomized controlled trials demonstrated that the potential benefits of the use of remifentanil not only include a profound protection against intraoperative stressful stimuli, but also rapid postoperative recovery, early weaning from mechanical ventilation, and extubation. Remifentanil shows ideal properties of sedative agents being often employed for minimally invasive cardiologic techniques, such as transcatheter aortic valve implantation and radio frequency treatment of atrial flutter, or diagnostic procedures such as transesophageal echocardiography. In intensive care units remifentanil is associated with a reduction in the time to tracheal extubation after cessation of the continuous infusion; other advantages could be more evident in patients with organ dysfunction. Effective and safe analgesia can be provided in case of short and painful procedures (i.e. chest drain removal). In conclusion, thanks to its peculiar properties, remifentanil will probably play a major role in critically ill cardiac patients. |
| | |
Authors:
|
Laura Ruggeri; Giovanni Landoni; Fabio Guarracino; Sabino Scolletta; Elena Bignami; Alberto Zangrillo |
Related Documents
:
|
21366368 - Safety of continuous propofol sedation for endoscopic procedures in elderly patients. 21510288 - Deployment of self-expanding metallic stents under fluoroscopic guidance in patients wi... 21179218 - Efficacy, safety, and tolerability of travoprost 0.004% bak-free versus prior treatment... 21283508 - Symptomatic glenoid loosening complicating total shoulder arthroplasty. 21810378 - The effect of the duration of clopidogrel use on hscrp levels after stenting the target... 3534198 - Glycine-based oral rehydration solution: reassessment of safety and efficacy. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Annals of cardiac anaesthesia Volume: 14 ISSN: 0974-5181 ISO Abbreviation: Ann Card Anaesth Publication Date: 2011 Jan-Apr |
Date Detail:
|
Created Date: 2011-01-03 Completed Date: 2011-05-18 Revised Date: 2011-10-03 |
Medline Journal Info:
|
Nlm Unique ID: 9815987 Medline TA: Ann Card Anaesth Country: India |
Other Details:
|
Languages: eng Pagination: 6-12 Citation Subset: IM |
Affiliation:
|
Department of Anesthesia and Intensive Care Medicine, Università Vita-Salute San Raffaele, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analgesics, Opioid
/
pharmacology Anesthesia / methods Anesthetics, Intravenous / pharmacology Cardiac Surgical Procedures* Critical Illness* Humans Hypnotics and Sedatives / pharmacology Intensive Care Units Piperidines / adverse effects, pharmacokinetics, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 0/Piperidines; 132875-61-7/remifentanil |
| Comments/Corrections | |
Comment In:
|
Ann Card Anaesth. 2011 Sep-Dec;14(3):242-3
[PMID:
21860204
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modified method of T-tube placement in cases of ruptured choledochal cyst having complete loss of an...
Next Document: Ketamine has no effect on oxygenation indices following elective coronary artery bypass grafting und...