| Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. | |
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MedLine Citation:
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PMID: 21780776 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this perspective, we present the key features of the N-C-P molecular fragment that govern the activity of the molecules that incorporate it. A general overview of known modes of action and target enzyme classes is briefly presented. Recent representative medicinal chemistry projects are described and discussed, including the achievements of our research group on leucine aminopeptidase and urease. Particular attention is given to the molecular aspects of the N-C-P mechanism of action and to the rational design of new compounds based on three-dimensional structures The potential future applications of this class of compounds are also discussed. |
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Authors:
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Artur Mucha; Pawel Kafarski; Lukasz Berlicki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-22 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: - ISSN: 1520-4804 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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