| Reliable microfluidic on-chip incubation of droplets in delay-lines. | |
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MedLine Citation:
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PMID: 19417899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Together with droplet creation, fusion and sorting, the incubation of droplets is one of the most important and essential operations for droplet-based microfluidic assays. This manuscript concerns the development of delay-lines, which are necessary to allow incubation of reactions for precise time periods. We analyze the problems associated with creating delay-lines for incubation in the minute to hour time range, which arise from back-pressure and from the dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay-line. We describe delay-line systems which resolve these problems and demonstrate their use to measure reaction kinetics over several minutes in droplets. |
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Authors:
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Lucas Frenz; Kerstin Blank; Eric Brouzes; Andrew D Griffiths |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-19 |
Journal Detail:
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Title: Lab on a chip Volume: 9 ISSN: 1473-0197 ISO Abbreviation: Lab Chip Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-06 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 1344-8 Citation Subset: IM |
Affiliation:
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Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université Louis Pasteur, 67083, Strasbourg Cedex, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enzymes Equipment Design Kinetics Microfluidic Analytical Techniques / instrumentation* Normal Distribution Pressure Time Factors Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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