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Reliable measurement of elastic modulus of cells by nanoindentation in an atomic force microscope.
MedLine Citation:
PMID:  22402160     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump method developed for viscoelastic materials gives elastic modulus values which are independent of the rate-jump magnitude. The results show that the rate-jump method can be used as a standard protocol for measuring elastic stiffness of living cells, since the measured values are intrinsic properties of the cells.
Authors:
Z L Zhou; A H W Ngan; B Tang; A X Wang
Publication Detail:
Type:  Journal Article     Date:  2011-12-03
Journal Detail:
Title:  Journal of the mechanical behavior of biomedical materials     Volume:  8     ISSN:  1878-0180     ISO Abbreviation:  J Mech Behav Biomed Mater     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101322406     Medline TA:  J Mech Behav Biomed Mater     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  134-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
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