| Reliable measurement of elastic modulus of cells by nanoindentation in an atomic force microscope. | |
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MedLine Citation:
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PMID: 22402160 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The elastic modulus of an oral cancer cell line UM1 is investigated by nanoindentation in an atomic force microscope with a flat-ended tip. The commonly used Hertzian method gives apparent elastic modulus which increases with the loading rate, indicating strong effects of viscoelasticity. On the contrary, a rate-jump method developed for viscoelastic materials gives elastic modulus values which are independent of the rate-jump magnitude. The results show that the rate-jump method can be used as a standard protocol for measuring elastic stiffness of living cells, since the measured values are intrinsic properties of the cells. |
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Authors:
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Z L Zhou; A H W Ngan; B Tang; A X Wang |
Publication Detail:
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Type: Journal Article Date: 2011-12-03 |
Journal Detail:
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Title: Journal of the mechanical behavior of biomedical materials Volume: 8 ISSN: 1878-0180 ISO Abbreviation: J Mech Behav Biomed Mater Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101322406 Medline TA: J Mech Behav Biomed Mater Country: Netherlands |
Other Details:
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Languages: eng Pagination: 134-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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