| Reliable high-speed coronary computed tomography in symptomatic patients. | |
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MedLine Citation:
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PMID: 17707184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Our objective was to prospectively evaluate the diagnostic performance of the high-speed dual-source computed tomography scanner (DSCT), with an increased temporal resolution (83 ms), for the detection of significant coronary lesions (> or =50% lumen diameter reduction) in a clinically wide range of patients. BACKGROUND: Cardiac motion artifacts may decrease coronary image quality with use of earlier computed tomography scanners that have a limited temporal resolution. METHODS: We prospectively studied 100 symptomatic patients (79 men, 21 women, mean age 61 +/- 11 years) with atypical (18%) or typical (55%) angina pectoris, or unstable coronary artery disease (27%) scheduled for conventional coronary angiography. Mean scan time was 8.58 +/- 1.52 s. Mean heart rate was 68 +/- 11 beats/min. Quantitative coronary angiography was used as the standard of reference. Irrespective of image quality or vessel size, all segments were included for analysis. RESULTS: Invasive coronary angiography demonstrated no significant disease in 23%, single-vessel disease in 31%, and multivessel disease in 46% of patients; 1,489 coronary segments, containing 220 significant (14.8%) stenoses, were available for analysis. Sensitivity, specificity, and positive and negative predictive values of DSCT coronary angiography for the detection of significant lesions on a segment-by-segment analysis were 95% (95% confidence interval [CI] 90 to 97), 95% (95% CI 93 to 96), 75% (95% CI 69 to 80), 99% (95% CI 98 to 99), respectively, and on a patient-based analysis 99% (95% CI 92 to 100), 87% (95% CI 65 to 97), 96% (95% CI 89 to 99), and 95% (95% CI 74 to 100), respectively. CONCLUSIONS: Noninvasive DSCT coronary angiography is highly sensitive to detect and to reliably rule out the presence of a significant coronary stenosis in patients presenting with atypical or typical angina pectoris, or unstable coronary artery disease. |
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Authors:
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Annick C Weustink; Willem B Meijboom; Nico R Mollet; Masato Otsuka; Fransesca Pugliese; Carlos van Mieghem; Roberto Malago; Niels van Pelt; Marcel L Dijkshoorn; Filippo Cademartiri; Gabriel P Krestin; Pim J de Feyter |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2007-08-06 |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 50 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-20 Completed Date: 2007-10-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 786-94 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Thoraxcenter, Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angina Pectoris / radiography Coronary Angiography / methods* Coronary Artery Disease / radiography Coronary Stenosis / radiography* Female Humans Male Middle Aged Prospective Studies Sensitivity and Specificity Tomography, X-Ray Computed* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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