| Reliable Identification of 'Truly Low' Thromboembolic Risk in Patients Initially Diagnosed with 'Lone' Atrial Fibrillation: The Belgrade Atrial Fibrillation Study. | |
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MedLine Citation:
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PMID: 22319004 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: -The CHA(2)DS(2)-VASc schema has recently been introduced to complement the CHADS(2) score and improve the identification of atrial fibrillation (AF) patients at 'truly low risk' for thromboembolism. We tested the predictive ability of the CHA(2)DS(2)-VASc, CHADS(2) and van Walraven risk stratification schemes in a cohort of 'lone' AF patients with a 12-year follow-up. METHODS AND RESULTS: -We conducted a registry-based, observational cohort study of 345 patients initially diagnosed with 'lone' AF between 1992 and 2007. At baseline, all patients had the CHADS(2) and van Walraven scores of 0, and 262(75.9%) had a CHA(2)DS(2)-VASc score=0. During follow-up (or within a year prior to stroke), 228 (66.1%), 234 (67.8%) and 150 patients (43.5%) retained the CHADS(2), van Walraven and CHA(2)DS(2)-VASc scores of 0, respectively. The overall rate of ischemic stroke was 0.19 (95%CI:0.18-0.20) per 100 patient-years. In the multivariable analysis, only the CHA(2)DS(2)-VASc score of 0 was significantly related to the absence of stroke (OR 5.1, 95%CI:1.5-16.8, p=0.008). Only the CHA(2)DS(2)-VASc score had a significant prediction ability (c-statistic 0.72 [0.61-0.84], p=0.031). CONCLUSIONS: -The CHA(2)DS(2)-VASc score reliably identified the 'lone' AF patients who were at 'truly low risk' for thromboembolism, and was the only tested risk stratification scheme with a significant predictive ability for thromboembolism amongst lone AF patients. |
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Authors:
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Tatjana S Potpara; Marija M Polovina; Marina M Licina; Jelena M Marinkovic; Milica S Prostran; Gregory Y H Lip |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-8 |
Journal Detail:
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Title: Circulation. Arrhythmia and electrophysiology Volume: - ISSN: 1941-3084 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474365 Medline TA: Circ Arrhythm Electrophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 University of Belgrade & Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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