Document Detail

Reliability and sensitivity of frozen-section pancreatic biopsy.
MedLine Citation:
PMID:  3970667     Owner:  NLM     Status:  MEDLINE    
A collaborative Veterans Administration and University of California, Davis Medical Center group of 586 patients with histologically proved pancreatic carcinoma was reviewed. During laparotomy, 159 patients underwent 251 frozen-section pancreatic biopsies with subsequent permanent section examination of the same tissue block. All 112 positive frozen-section diagnoses were corroborated on permanent sectioning. The 47 patients with false-negative biopsy specimens were equally divided between sampling and interpretation error. We conclude that in this group of 159 pancreatic cancer patients, 30% failed to be correctly diagnosed by intraoperative frozen-section biopsy. This failure was due to patient sampling and interpretation error in equal proportion. Interpretation error rates were not influenced by the type or number of biopsies. Patient sampling error is apparently reduced by repeated biopsy, and specimen sampling error occurred less frequently with wedge biopsy.
R P Campanale; C F Frey; L R Farias; P L Twomey; J M Guernsey; R Keehn; G Higgins
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  120     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-03-21     Completed Date:  1985-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  AIM; IM    
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MeSH Terms
Biopsy / methods*
False Negative Reactions
Frozen Sections*
Intraoperative Period
Pancreas / pathology*
Pancreatic Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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