| Reliability of mean transit time obtained using perfusion-weighted MR imaging; comparison with positron emission tomography. | |
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MedLine Citation:
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PMID: 12620543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this project was to assess the reliability of the cerebral mean transit time (MTT) obtained using perfusion-weighted MR imaging by comparing it with the MTT obtained when performing positron emission tomography (PET). Ten patients with chronic occlusive cerebrovascular disease were investigated. They had either unilateral internal carotid artery occlusion or middle cerebral artery occlusion. The regions-of-interest were placed in non-infarcted areas within the territory of the middle cerebral artery on the affected side. Control regions-of-interest were placed in mirrored regions of the contralateral side. Linear regression analyses were performed using the parameters of the MTT obtained with perfusion-weighted MR imaging and the MTT, cerebral blood flow, vascular reactivity, and oxygen extraction fraction obtained with PET. The respective MTTs of the affected and non-affected sides obtained with perfusion-weighted MR imaging versus those with PET were 7.3 +/- 2.2 s and 6.0 +/- 1.2 s versus 8.2 +/- 3.0 s and 6.4 +/- 1.7 s. The MTT obtained using perfusion-weighted MR imaging and PET demonstrated statistically significant correlation (r = 0.87, p < 0.0001). The MTT obtained with perfusion-weighted MR imaging correlated statistically with cerebral blood flow (r = -0.74, p < 0.001), vascular reactivity (r = -0.73, p < 0.001) and oxygen extraction fraction (r = 0.61, p < 0.01). Similarly, the MTT obtained using PET statistically correlated with cerebral blood flow (r = -0.78, p < 0.0001), vascular reactivity (r = -0.51, p < 0.05) and oxygen extraction fraction (r = 0.68, p < 0.01). The reliability of the MTT obtained using perfusion-weighted MR imaging appears to be approximately equal to that obtained with positron emission tomography. |
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Authors:
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Futoshi Mihara; Yasuo Kuwabara; Atsuo Tanaka; Takashi Yoshiura; Masayuki Sasaki; Tsuyoshi Yoshida; Kouji Masuda; Toshio Matsushima |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 21 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-03-06 Completed Date: 2003-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 33-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Radiology, Kyushu University, Fukuoka, Japan. fmihara@radiol.med.kyushu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cerebral Infarction / diagnosis* Child Chronic Disease Female Humans Magnetic Resonance Angiography* Male Middle Aged Regression Analysis Reproducibility of Results Time Factors Tomography, Emission-Computed |
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