Document Detail

Reliability of magnetic resonance imaging for measuring the volumetric indices in autosomal-dominant polycystic kidney disease: correlation with hypertension and renal function.
MedLine Citation:
PMID:  16636585     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to determine if renal volumetric indices can be accurately measured using MRI, and if these volumetric indices are associated with hypertension and renal function in patients with autosomal-dominant polycystic kidney disease (ADPKD). METHODS: For testing the accuracy of the MRI-based volume measurements that we proposed for clinical trial, we designed phantoms to simulate cysts within the kidney. Fifty-six patients with ADPKD were included in this study, and their respiratory compensated T2-weighted fast spin-echo images were acquired. The total kidney volume (Vt), cyst volume (Vc), and noncystic parenchymal volume (Vp) were measured and the percent cyst volume (Pc) was calculated. These volumetric indices were compared with the disease progression in the ADPKD patients. RESULTS: The MRI measures of the phantoms were accurate. The Vt, Vc and Pc were significantly greater in the hypertensive group (n = 35) than in the normotensive group (n = 21) (p < 0.01). The Vt, Vc and Pc were significantly greater in the renal failure group (n = 23) than in the normal renal function group (n = 33) (p < 0.01). The Vt, Vc, and Pc were inversely correlated with the creatinine clearance. CONCLUSION: MRI is a reliable method to measure renal volumetric indices. The MRI-based volume measurements can be employed as useful markers for the progression of disease in ADPKD patients.
Young Rae Lee; Kyu-Beck Lee
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Publication Detail:
Type:  Journal Article     Date:  2006-04-24
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  103     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-08-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c173-80     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel
Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Jong-no ku, Seoul, Korea.
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MeSH Terms
Aged, 80 and over
Creatinine / blood
Disease Progression
Hypertension / pathology,  physiopathology
Kidney / pathology*,  physiopathology
Kidney Function Tests
Magnetic Resonance Imaging*
Middle Aged
Organ Size
Phantoms, Imaging
Polycystic Kidney, Autosomal Dominant / diagnosis*,  pathology,  physiopathology
Reg. No./Substance:

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